1998
Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation.
Thompson D, Altiere R. Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 19-24. PMID: 9435155.Peer-Reviewed Original ResearchConceptsAirway smooth muscle contractionSmooth muscle contractionInduction of toneMuscle contractionNerve stimulationNitric oxide-dependent componentAirway smooth muscle toneNitric oxide synthase inhibitorOvalbumin-sensitized guinea pigsNerve-induced relaxationNonadrenergic noncholinergic relaxationElectrical field stimulationOxide synthase inhibitorSmooth muscle toneLevel of toneNoncholinergic relaxationTracheal contractionRelaxant responsesContractile actionAirway tissueNerve activationContractile agonistsMuscle toneField stimulationSynthase inhibitor
1997
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus.
Cibulsky S, Thompson D. Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 1102-9. PMID: 9399982.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensBronchiGuinea PigsIn Vitro TechniquesLeukotriene D4LisinoprilMaleMuscle ContractionTachykininsThiorphanConceptsD4-induced contractionAntigen-induced contractionGuinea-pig bronchiLeukotriene D4Endogenous tachykininsPig bronchiNeutral endopeptidaseLeukotriene D4-induced contractionMast cell-derived mediatorsAirway smooth muscle cellsConcentration of tachykininOvalbumin-induced contractionGuinea pig airwaysCell-derived mediatorsPresence of tetrodotoxinNeurokinin receptor antagonistsAngiotensin-converting enzymeSmooth muscle cellsTachykinin involvementTachykininergic responsesContractile actionPig airwaysReceptor antagonistTetrodotoxin treatmentTachykinins
1995
Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig Trachea
Lindsay G, Diamond L, Thompson D, Cibulsky S, Altiere R. Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig Trachea. CHEST Journal 1995, 107: 125s. PMID: 7874990, DOI: 10.1378/chest.107.3_supplement.125s.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAutonomic Nervous SystemGuinea PigsIn Vitro TechniquesMuscle RelaxationNitric OxideTrachea
1988
The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways
Thompson D, Altiere R, Diamond L. The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways. Peptides 1988, 9: 443-447. PMID: 3131749, DOI: 10.1016/0196-9781(88)90284-7.Peer-Reviewed Original ResearchConceptsIntrapulmonary bronchiInhibitory responsesNonadrenergic noncholinergic inhibitory responsesEffective competitive antagonistNANC inhibitory responsesNANC relaxation responsesNoncholinergic inhibitory responsesRole of VIPVIP receptor antagonistVasoactive intestinal peptideEffects of antagonistsHigher VIP concentrationsVIP concentrationsVIP antagonistFeline airwaysIntestinal peptideReceptor antagonistVIP receptorsCompetitive antagonistNervous stimulationAntagonistRelaxation responseVIPGRFResponseThe effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig
Thompson D, Wells J, Altiere R, Diamond L. The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig. European Journal Of Pharmacology 1988, 145: 231-237. PMID: 3350044, DOI: 10.1016/0014-2999(88)90237-3.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBronchiCatsElectric StimulationEpitheliumFemaleGuinea PigsHistamineIn Vitro TechniquesMaleMuscle ContractionSerotoninTracheaConceptsElectrical field stimulationEpithelium removalField stimulationHilar bronchusNon-cholinergic inhibitory responsesTissue sensitivityRelaxation responseNANC relaxation responsesGuinea pig tracheaBronchial sensitivityAirway preparationsContractile responseContractile actionContractile agonistsCentral airwaysPig tracheaAirway epitheliumInhibitory responsesPharmacological agonistsFeline tracheaGuinea pigsBronchusStimulationAgonistsTrachea