2013
Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity
Jang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radical Biology And Medicine 2013, 68: 80-86. PMID: 24316006, PMCID: PMC3941192, DOI: 10.1016/j.freeradbiomed.2013.11.028.Peer-Reviewed Original ResearchConceptsHuman bronchial epithelial cellsImmortalized human bronchial epithelial cellsCigarette smokeALDH enzymatic activityCigarette smoke-induced DNA damageAldehyde dehydrogenase 3A1Smoke-induced DNA damagePrimary human bronchial epithelial cellsEpithelial cellsCSE-exposed cellsCSE-induced cytotoxicityBronchial epithelial cellsDNA damageExtract exposureMRNA levelsEffects of overexpression
1997
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus.
Cibulsky S, Thompson D. Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 1102-9. PMID: 9399982.Peer-Reviewed Original ResearchConceptsD4-induced contractionAntigen-induced contractionGuinea-pig bronchiLeukotriene D4Endogenous tachykininsPig bronchiNeutral endopeptidaseLeukotriene D4-induced contractionMast cell-derived mediatorsAirway smooth muscle cellsConcentration of tachykininOvalbumin-induced contractionGuinea pig airwaysCell-derived mediatorsPresence of tetrodotoxinNeurokinin receptor antagonistsAngiotensin-converting enzymeSmooth muscle cellsTachykinin involvementTachykininergic responsesContractile actionPig airwaysReceptor antagonistTetrodotoxin treatmentTachykinins
1992
Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways.
Altiere R, Diamond L, Thompson D. Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. Journal Of Pharmacology And Experimental Therapeutics 1992, 260: 98-103. PMID: 1309883.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAtropineAutonomic Nervous SystemBronchiCalcium ChannelsCapsaicinCholineElectric StimulationEpinephrineGuanethidineGuinea PigsIndomethacinMaleMuscle ContractionNeurons, AfferentNeurons, EfferentOmega-Conotoxin GVIAPeptides, CyclicPropranololSynaptic TransmissionTachykininsTracheaConceptsSensitive calcium channelsCalcium channelsCholinergic excitatoryNeuronal N-type voltage-sensitive calcium channelsN-type voltage-sensitive calcium channelsNonadrenergic noncholinergic (NANC) inhibitory nervesNonadrenergic noncholinergic inhibitory responsesVoltage-sensitive calcium channelsNoncholinergic inhibitory nervesNoncholinergic inhibitory responsesGuinea pig airwaysGuinea-pig bronchiElectrical field stimulationGuinea pig tracheaMarine snail Conus geographusConcentration-response relationshipAirway nervesAutonomic neurotransmissionTachykininergic responsesExogenous acetylcholineInhibitory nervesContractile responseConotoxin GVIAPig airwaysExcitatory responses
1990
NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE
Thompson D, Altiere R, Diamond L. NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE. Clinical And Experimental Pharmacology And Physiology 1990, 17: 83-97. PMID: 2328544, DOI: 10.1111/j.1440-1681.1990.tb01291.x.Peer-Reviewed Original Research
1988
The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways
Thompson D, Altiere R, Diamond L. The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways. Peptides 1988, 9: 443-447. PMID: 3131749, DOI: 10.1016/0196-9781(88)90284-7.Peer-Reviewed Original ResearchConceptsIntrapulmonary bronchiInhibitory responsesNonadrenergic noncholinergic inhibitory responsesEffective competitive antagonistNANC inhibitory responsesNANC relaxation responsesNoncholinergic inhibitory responsesRole of VIPVIP receptor antagonistVasoactive intestinal peptideEffects of antagonistsHigher VIP concentrationsVIP concentrationsVIP antagonistFeline airwaysIntestinal peptideReceptor antagonistVIP receptorsCompetitive antagonistNervous stimulationAntagonistRelaxation responseVIPGRFResponseThe effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig
Thompson D, Wells J, Altiere R, Diamond L. The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig. European Journal Of Pharmacology 1988, 145: 231-237. PMID: 3350044, DOI: 10.1016/0014-2999(88)90237-3.Peer-Reviewed Original ResearchConceptsElectrical field stimulationEpithelium removalField stimulationHilar bronchusNon-cholinergic inhibitory responsesTissue sensitivityRelaxation responseNANC relaxation responsesGuinea pig tracheaBronchial sensitivityAirway preparationsContractile responseContractile actionContractile agonistsCentral airwaysPig tracheaAirway epitheliumInhibitory responsesPharmacological agonistsFeline tracheaGuinea pigsBronchusStimulationAgonistsTrachea