Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 2010, 5: 30. PMID: 21106488, PMCID: PMC3390169, DOI: 10.1186/1479-7364-5-1-30.Peer-Reviewed Original ResearchConceptsHelical cytokinesCell typesAmino acid conservationEvolutionary divergenceOrthologous proteinsEvolutionary relationshipsGene familyImmune cell differentiationCommon structural motifBiological functionsCell differentiationUnique structural featuresExact functionStructural featuresGroup of cytokinesMajor groupsCell proliferationImportant roleImmune systemReceptor-binding propertiesHost immune systemStructural motifsStructural informationContinual competitionNumber of interleukin