1998
Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation.
Thompson D, Altiere R. Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 19-24. PMID: 9435155.Peer-Reviewed Original ResearchConceptsAirway smooth muscle contractionSmooth muscle contractionInduction of toneMuscle contractionNerve stimulationNitric oxide-dependent componentAirway smooth muscle toneNitric oxide synthase inhibitorOvalbumin-sensitized guinea pigsNerve-induced relaxationNonadrenergic noncholinergic relaxationElectrical field stimulationOxide synthase inhibitorSmooth muscle toneLevel of toneNoncholinergic relaxationTracheal contractionRelaxant responsesContractile actionAirway tissueNerve activationContractile agonistsMuscle toneField stimulationSynthase inhibitor
1992
Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle
Thompson D, Diamond L, Altiere R. Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulmonary Pharmacology & Therapeutics 1992, 5: 251-255. PMID: 1477481, DOI: 10.1016/0952-0600(92)90067-q.Peer-Reviewed Original ResearchConceptsGuinea pig tracheaGuinea pig tracheal smooth muscleInhibitory actionAlpha-adrenoceptor modulationCholinergic excitatory nervesCholinergic excitatory responsesIntermittent nerve stimulationAlpha-adrenoceptor agonistsPresynaptic inhibitory actionPresynaptic inhibitory effectAction of norepinephrineUse of norepinephrineNorepinephrine-induced inhibitionTracheal smooth musclePretreatment of tissuesConcentration-dependent inhibitionConcentration-dependent mannerCholinergic contractionsPresynaptic alphaCholinergic nervesExcitatory nervesNerve stimulationCholinergic responsesExcitatory responsesSmooth muscle
1990
Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig Tracheae
Thompson D, Diamond L, Altiere R. Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig Tracheae. American Journal Of Respiratory And Critical Care Medicine 1990, 142: 1119-1123. PMID: 2240834, DOI: 10.1164/ajrccm/142.5.1119.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNANC inhibitory responsesGuinea pig tracheaConcentration-response curvesInhibitory responsesIntestinal peptideInhibitory systemPig tracheaNonadrenergic noncholinergic inhibitory responsesVIP concentration-response curveExogenous vasoactive intestinal peptideRelaxation responseExogenous VIP administrationNANC inhibitory neurotransmitterNANC nerve stimulationNANC relaxation responsesNoncholinergic inhibitory responsesElectrical field stimulationSoybean trypsin inhibitorAdrenergic inhibitoryTachykinin depletionCholinergic excitatoryVIP administrationAutonomic nervesNerve stimulationPresynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea.
Thompson D, Diamond L, Altiere R. Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 306-11. PMID: 2164097.Peer-Reviewed Original ResearchConceptsGuinea pig tracheaNANC inhibitory nervesAlpha-2 adrenoceptor agonistPig tracheaInhibitory nervesAdrenoceptor agonistsExcitatory nervesNerve stimulationAdrenoceptor antagonistInhibitory responsesAlpha-1 adrenoceptor agonistNonadrenergic noncholinergic inhibitory responsesPresynaptic alpha-2 adrenoceptorsAlpha-2 adrenoceptor antagonistAlpha-1 adrenoceptor antagonistAlpha-adrenoceptor modulationCholinergic excitatory nervesNANC inhibitory responsesNoncholinergic excitatory nervesNoncholinergic inhibitory responsesAction of clonidineAlpha-2 adrenoceptorsSympathetic nerve stimulationInhibitory nerve stimulationVasoactive intestinal peptide