Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle
Thompson D, Diamond L, Altiere R. Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulmonary Pharmacology & Therapeutics 1992, 5: 251-255. PMID: 1477481, DOI: 10.1016/0952-0600(92)90067-q.Peer-Reviewed Original ResearchConceptsGuinea pig tracheaGuinea pig tracheal smooth muscleInhibitory actionAlpha-adrenoceptor modulationCholinergic excitatory nervesCholinergic excitatory responsesIntermittent nerve stimulationAlpha-adrenoceptor agonistsPresynaptic inhibitory actionPresynaptic inhibitory effectAction of norepinephrineUse of norepinephrineNorepinephrine-induced inhibitionTracheal smooth musclePretreatment of tissuesConcentration-dependent inhibitionConcentration-dependent mannerCholinergic contractionsPresynaptic alphaCholinergic nervesExcitatory nervesNerve stimulationCholinergic responsesExcitatory responsesSmooth muscleOmega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways.
Altiere R, Diamond L, Thompson D. Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. Journal Of Pharmacology And Experimental Therapeutics 1992, 260: 98-103. PMID: 1309883.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAtropineAutonomic Nervous SystemBronchiCalcium ChannelsCapsaicinCholineElectric StimulationEpinephrineGuanethidineGuinea PigsIndomethacinMaleMuscle ContractionNeurons, AfferentNeurons, EfferentOmega-Conotoxin GVIAPeptides, CyclicPropranololSynaptic TransmissionTachykininsTracheaConceptsSensitive calcium channelsCalcium channelsCholinergic excitatoryNeuronal N-type voltage-sensitive calcium channelsN-type voltage-sensitive calcium channelsNonadrenergic noncholinergic (NANC) inhibitory nervesNonadrenergic noncholinergic inhibitory responsesVoltage-sensitive calcium channelsNoncholinergic inhibitory nervesNoncholinergic inhibitory responsesGuinea pig airwaysGuinea-pig bronchiElectrical field stimulationGuinea pig tracheaMarine snail Conus geographusConcentration-response relationshipAirway nervesAutonomic neurotransmissionTachykininergic responsesExogenous acetylcholineInhibitory nervesContractile responseConotoxin GVIAPig airwaysExcitatory responses