Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice
Kisley L, Barrett B, Dwyer-Nield L, Bauer A, Thompson D, Malkinson A. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis 2002, 23: 1653-1660. PMID: 12376474, DOI: 10.1093/carcin/23.10.1653.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsLung tumor formationPulmonary inflammationLung tumorigenesisLung tumorsMacrophage infiltrationPGE2 productionTumor formationMice fed control dietCOX-2-specific inhibitorsTwo-stage carcinogenesis protocolCelecoxib-treated miceLung cancer developmentAnti-inflammatory drugsProduction of eicosanoidsFed control dietCyclooxygenase-enzyme expressionDifferent organ systemsChronic administrationPGE2 levelsVascular leakageClinical trialsCarcinogenesis protocolMurine modelHigh risk