Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application
Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application. Pharmacological Reviews 2012, 64: 520-539. PMID: 22544865, PMCID: PMC3400832, DOI: 10.1124/pr.111.005538.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRetinoic acid signalingSuperfamily of enzymesCellular defense mechanismsALDH isozymesCellular homeostasisMechanism of actionAcid signalingCorneal crystallinsSubstrate specificityIsozyme-selective inhibitorsALDH enzymesToxicological functionsKey enzymeHuman ALDHHuman diseasesHuman cancersDefense mechanismsPharmacological inhibitionToxicological roleReactive aldehydesALDH inhibitorsIsozymesEnzymeUltraviolet radiation-induced damagePivotal roleMolecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal
Black W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radical Biology And Medicine 2012, 52: 1937-1944. PMID: 22406320, PMCID: PMC3457646, DOI: 10.1016/j.freeradbiomed.2012.02.050.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenasesOxidative stress responseCellular defense mechanismsOxidative stressHuman ALDH3A1Proteasome functionMolecular mechanismsPrevents apoptosisStress responseCellular protectionLipid peroxidationAdverse effectsWestern blot analysisAldehydic moleculesGlutathione homeostasisALDH3A1 expressionCell viability assaysMetabolic functionsALDH3A1Blot analysisDefense mechanismsProtein adduct formationCell linesCell viabilityViability assays