2011
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development
Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Experimental Hematology 2011, 40: 318-329.e2. PMID: 22198153, DOI: 10.1016/j.exphem.2011.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehydesAnimalsAnimals, CongenicB-LymphocytesBone Marrow TransplantationCell CountCell CycleCell LineageCells, CulturedColony-Forming Units AssayDNA DamageEnzyme InductionGene Expression RegulationHematopoiesisHematopoietic Stem CellsLymphopeniaMiceMice, Inbred C57BLMice, KnockoutP38 Mitogen-Activated Protein KinasesRadiation ChimeraReactive Oxygen SpeciesRetinal DehydrogenaseSignal TransductionConceptsB cell developmentHematopoietic stem cellsReactive oxygen speciesMitogen-activated protein kinase activityP38 mitogen-activated protein kinase activityProtein kinase activityExcess reactive oxygen speciesOxygen speciesReactive aldehydesStem cell numbersHematopoietic stem cell numbersReactive oxygen species levelsEarly B cellsNumber of HSCsHSC biologyCell cycle distributionKinase activityOxygen species levelsAldh1a1 deficiencyGene expressionSpecies levelIntracellular signalingAldehyde dehydrogenasesDNA damageCell cycling
2000
Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells
Koffler L, Roshong S, Park I, Cesen‐Cummings K, Thompson D, Dwyer‐Nield L, Rice P, Mamay C, Malkinson A, Ruch R. Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells. Journal Of Cellular Biochemistry 2000, 79: 347-354. PMID: 10972973, DOI: 10.1002/1097-4644(20001201)79:3<347::aid-jcb10>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinomaCell CommunicationCell Cycle ProteinsCell DivisionConnexinsCyclin D1Cyclin-Dependent Kinase Inhibitor p27CytokinesDiffusionFluorescent DyesG1 PhaseGap JunctionsGene Expression Regulation, NeoplasticLiver Neoplasms, ExperimentalLung NeoplasmsMiceMicrotubule-Associated ProteinsNeoplasm ProteinsNitric OxideProtein KinasesRatsReceptors, Growth FactorRecombinant Fusion ProteinsTransfectionTumor Cells, CulturedTumor Suppressor ProteinsConceptsGap junctional intercellular communicationRat liver epithelial cellsConnexin expressionE9 cellsLiver epithelial cellsGrowth controlDefective growth controlCyclin D1Growth-related functionsTransfection of Cx43Cell cycle regulatorsCell linesEpithelial cellsGap junction proteinCarcinoma cellsMouse lung carcinoma cellsJunctional intercellular communicationLess cyclin D1Cell cycle distributionCycle regulatorsForced expressionIntercellular communicationS phaseP27kip-1Lung carcinoma cells