2022
Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models
Wang Y, Charkoftaki G, Davidson E, Orlicky D, Tanguay R, Thompson D, Vasiliou V, Chen Y. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion In Environmental Science & Health 2022, 29: 100389. PMID: 37483863, PMCID: PMC10361651, DOI: 10.1016/j.coesh.2022.100389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxidative stressUnique mouse modelRelevant low dosesDirect genotoxic effectsLiver cytotoxicityCYP2E1 activationMouse modelAnimal modelsHuman studiesCarcinogenic pathwaysLiver carcinogenicityLow dosesCausal roleGenotoxic effectsHuman exposureUndetermined mechanismPublic healthCarcinogenicityLiver genotoxicityDrinking water contaminantsMechanistic dataGenotoxicityFuture animalCytotoxicityCYP2E1
2013
The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System
Heit C, Dong H, Chen Y, Thompson DC, Deitrich RA, Vasiliou VK. The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System. Subcellular Biochemistry 2013, 67: 235-247. PMID: 23400924, PMCID: PMC4314297, DOI: 10.1007/978-94-007-5881-0_8.ChaptersConceptsCentral nervous systemNervous systemBlood-brain barrierRole of CYP2E1Certain brain cellsCytochrome P450 2E1Particular brain regionsMotor incoordinationBrain barrierSleep inductionEthanol consumptionBrain cellsAlcohol consumptionBrain regionsP450 2E1Alcohol metabolismEthanol metabolismBehavioral effectsCYP2E1Major enzymeLocal productionMetabolismIncoordinationBrain