2023
Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008
Siwakoti R, Cathey A, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008. Environmental Research 2023, 237: 116967. PMID: 37634691, PMCID: PMC10913455, DOI: 10.1016/j.envres.2023.116967.Peer-Reviewed Original ResearchConceptsLarge-for-gestational agePreterm birth subtypesBayesian kernel machine regressionSize-for-gestational ageSmall-for-gestational agePreterm birthFetal sexPregnancy outcomesSex-specific estimatesIncreased risk of adverse pregnancy outcomesInterquartile range increaseRisk of adverse pregnancy outcomesBayesian kernel machine regression analysisEarly pregnancy samplesAdverse pregnancy outcomesCase-control studyPrenatal PFAS exposureAssociations of polyfluoroalkyl substancesBW z-scoreEffects of polyfluoroalkyl substancesKernel machine regressionEffect modificationEffects of prenatal exposureRange increaseStratified analysis
2022
Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental PollutantsFemaleGestational AgeHormonesHumansInfant, NewbornMalePhthalic AcidsPregnancyPremature BirthConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Cathey A, Watkins D, Rosario Z, Vega C, Mukherjee B, O’Neill M, Loch-Caruso R, Alshawabkeh A, Cordero J, Meeker J. Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner. Frontiers In Endocrinology 2021, 12: 742145. PMID: 34603214, PMCID: PMC8479114, DOI: 10.3389/fendo.2021.742145.Peer-Reviewed Original ResearchConceptsTime of deliveryFetal sexBody mass indexGestational ageMaternal agePreterm premature rupture of membranesPre-pregnancy body mass indexHormone concentrationsFetal sex-specific effectsPremature rupture of membranesOverall preterm birthPreterm premature ruptureSpontaneous preterm laborRupture of membranesReduced gestational ageOdds of PTBTime of laborSignificant public health problemTobacco smoke exposureGestational hormonesSpontaneous PTBPreterm laborWeeks gestationPreterm birthLongitudinal birth cohortMaternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
Aung M, Ashrap P, Watkins D, Mukherjee B, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific Reports 2021, 11: 8115. PMID: 33854141, PMCID: PMC8046995, DOI: 10.1038/s41598-021-87472-9.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthBiomarkers of pregnancy outcomesGestational age neonatesPreterm birthAge neonatesPregnancy outcomesDegree of hydrocarbon chain saturationIncreased riskNeonatal anthropometric parametersAssociated with increased riskPlasmenyl phosphatidylethanolamineMaternal lipidomeWeeks gestationGestational ageLipidomic signatureAnthropometric parametersLiquid chromatography tandem mass spectrometryLipidomic profilesLipid metabolitesHydrocarbon chain saturationPlasma samplesBirthLogistic regressionHigh-performance liquid chromatography tandem mass spectrometryNeonates
2020
Application of an analytical framework for multivariate mediation analysis of environmental data
Aung M, Song Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Meeker J, Mukherjee B. Application of an analytical framework for multivariate mediation analysis of environmental data. Nature Communications 2020, 11: 5624. PMID: 33159049, PMCID: PMC7648785, DOI: 10.1038/s41467-020-19335-2.Peer-Reviewed Original ResearchMaternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Boss J, Richards M, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico. Environment International 2020, 138: 105606. PMID: 32179314, PMCID: PMC7198231, DOI: 10.1016/j.envint.2020.105606.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremFemaleGestational AgeHumansInfant, NewbornMaternal ExposureMetalloidsPregnancyPremature BirthPuerto RicoConceptsBayesian kernel machine regressionShorter gestational agePreterm birthGestational ageEnvironmental risk scoreBirth outcomesMetal concentrationsNon-essential metal(loid)sHigher risk of preterm birthRisk of preterm birthLow-level prenatal lead exposureInterquartile rangeOdds of preterm birthAssociated with higher risk of preterm birthRisk scoreEffects of metalsPredictors of birth outcomesAssociated with birth outcomesBayesian kernel machine regression modelsBirthweight z-scoreAssociated with adverse birth outcomesAssociated with higher riskAdverse birth outcomesKernel machine regressionPuerto Rico Testsite
2018
The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2018, 169: 41-51. PMID: 30412856, PMCID: PMC6347499, DOI: 10.1016/j.envres.2018.10.030.Peer-Reviewed Original ResearchConceptsAssociated with gestational ageGestational ageOdds of SGAInfant sexBirth outcomesStudy visitsVisit 1Odds of preterm birthOdds of LGAAssociated with adverse birth outcomesBirthweight z-scoreBiomarker concentrationsAdverse birth outcomesPuerto Rico TestsitePreterm birthPregnant womenBirth weightUrinary biomarker concentrationsExposure biomarkersLogistic regression modelsVisit 3SGADecreased oddsZ-scoreCalculate oddsAssociations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores
Boss J, Zhai J, Aung M, Ferguson K, Johns L, McElrath T, Meeker J, Mukherjee B. Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores. Environmental Health 2018, 17: 56. PMID: 29925380, PMCID: PMC6011420, DOI: 10.1186/s12940-018-0400-3.Peer-Reviewed Original ResearchConceptsMono-2-ethyl-5-carboxypentyl phthalateEnvironmental risk scoreGestational ageHazard ratioPreterm birthRisk scoreInterquartile rangeIncreased odds of preterm birthCases of preterm birthOdds of preterm birthUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsUrinary phthalate metabolitesPhthalate metabolite measurementsCox proportional hazards modelsInterquartile range changeTime to deliveryProportional hazards modelLongitudinal birth cohortSingle-pollutant analysesSignificant public health concernUrinary metabolite concentrationsBackgroundPreterm birthPregnant womenExposure to phthalates
2016
Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure
Cantonwine D, Ferguson K, Mukherjee B, Chen Y, Smith N, Robinson J, Doubilet P, Meeker J, McElrath T. Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure. PLOS ONE 2016, 11: e0146532. PMID: 26731406, PMCID: PMC4701464, DOI: 10.1371/journal.pone.0146532.Peer-Reviewed Original ResearchConceptsFetal growthCohort study populationContemporary obstetric practiceZ-scoreNon-anomalous pregnanciesFetal sizeAssociated with increased fetal sizeClinical dataIncreased risk of perinatal morbidityMixed modelsRisk of perinatal morbidityStandard populationAssociated with fetal growthMeasures of fetal growthPrenatal careAssociated with factorsLinear mixed modelsMaternal BMIObstetric practiceEpidemiological researchMaternal smokingTrimester ultrasound evaluationSuboptimal fetal growthUS populationImpact fetal growth