2018
Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, Wicklund K, Eder B, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. Respiratory Research 2018, 19: 228. PMID: 30463560, PMCID: PMC6249926, DOI: 10.1186/s12931-018-0922-9.Peer-Reviewed Original ResearchConceptsViral infectionLung functionAbsence of viral infectionIL-13IL-4Viral-induced asthma exacerbationsRespiratory illnessRespiratory viral infectionsAssociated with increased cytokinesPro-inflammatory cytokinesLung function declineSelf-reported respiratory illnessInfluence of viral infectionAirway cytokinesMDA5 mRNACXCL10 mRNACytokine levelsAirway responsivenessNasal lavageAirflow obstructionAssociated with FVCAsthma exacerbationsAssociated with decreased lung functionInflammatory responseNasal samplesAssociations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumference
2016
Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies
Ferguson K, Meeker J, McElrath T, Mukherjee B, Cantonwine D. Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal Of Obstetrics And Gynecology 2016, 216: 527.e1-527.e9. PMID: 28043842, PMCID: PMC5420472, DOI: 10.1016/j.ajog.2016.12.174.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-aNormotensive pregnanciesC-reactive proteinMeasures of inflammationHazard ratioOxidative stress biomarkersInterleukin-1bTime pointsInflammation biomarkersStudy visitsTime of preeclampsia diagnosisPrediction of preeclampsiaOxidative stressHigher body mass indexOxidative stress biomarker 8-isoprostaneStress biomarkersCox proportional hazards modelsCompared to other time pointsBody mass indexProspective birth cohortCalculate hazard ratiosSmall study populationPanel of inflammationFactor AProportional hazards modelRepeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy
Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reproductive Toxicology 2016, 66: 93-98. PMID: 27751756, PMCID: PMC5125888, DOI: 10.1016/j.reprotox.2016.10.002.Peer-Reviewed Original ResearchConceptsInterquartile range increaseBisphenol AOxidative stressRange increaseUrinary bisphenol A concentrationsC-reactive proteinBiomarkers of inflammationIL-6 concentrationsAdverse birth outcomesPrimary mechanism of actionAssociated with significant increasesRepeated measures analysisBisphenol A exposureBiomarkers of oxidative stressBisphenol A concentrationsMechanism of actionPregnant womenFetal developmentImpact pregnancyInflammation markersBirth outcomesOxidative stress biomarkersIL-6BPA exposurePregnancy
2014
Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy. American Journal Of Reproductive Immunology 2014, 72: 326-336. PMID: 24807462, PMCID: PMC4573571, DOI: 10.1111/aji.12265.Peer-Reviewed Original ResearchConceptsPreterm birthC-reactive proteinAssociated with increased oddsInflammation markersAssociated with increased odds of spontaneous preterm birthIL-10Associated with increased risk of preterm birthOdds of spontaneous preterm birthEtiology of preterm deliveryPredictors of preterm birthIL-6Risk of preterm birthPreterm premature ruptureSpontaneous preterm laborSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProfile of inflammatory cytokinesAssociated with increased riskCase-control studyPreterm laborPreterm pregnanciesPreterm deliveryGestational agePremature rupture
2012
Nasal cytokine responses to natural colds in asthmatic children
Lewis T, Henderson T, Carpenter A, Ramirez I, McHenry C, Goldsmith A, Ren X, Mentz G, Mukherjee B, Robins T, Joiner T, Mohammad L, Nguyen E, Burns M, Burke D, Hershenson M. Nasal cytokine responses to natural colds in asthmatic children. Clinical & Experimental Allergy 2012, 42: 1734-1744. PMID: 23181789, PMCID: PMC4219353, DOI: 10.1111/cea.12005.Peer-Reviewed Original ResearchConceptsViral infectionMarker elevationSymptom scoresMarkers of viral infectionRespiratory viral infectionsRobust innate immune responsePresence of viral infectionRespiratory symptom scoresMultiplex immune assaysRespiratory tract symptomsSelf-reported respiratory illnessCCL11/eotaxin-1IFN-responsive genesInnate immune responseWeeks of assessmentNasal aspiratesCXCL10/IP-10CCL7/MCP-3IFN-gCCL2/MCP-1IRF7 mRNACXCL8/IL-8Asthma exacerbationsImmune responseMRNA signal