An efficient and computationally robust statistical method for analyzing case-control mother–offspring pair genetic association studies
Zhang H, Mukherjee B, Arthur V, Hu G, Hochner H, Chen J. An efficient and computationally robust statistical method for analyzing case-control mother–offspring pair genetic association studies. The Annals Of Applied Statistics 2020, 14: 560-584. DOI: 10.1214/19-aoas1298.Peer-Reviewed Original ResearchEnvironmental risk factorsRisk factorsMaternal environmental risk factorsOffspring genetic effectsPerinatal environmental risk factorsGenetic association studiesFinite sample performancePregnancy healthGenetic risk factorsAssessment of pre-Extensive simulation studyGestational diabetes mellitusIncreased statistical efficiencyLogistic regressionAssociation studiesMaternal genotypeSample performanceMendelian transmissionProfile likelihoodRegression modelsOffspring genotypesEarly-lifeInference proceduresLagrange multiplier methodLikelihood method