Featured Publications
Exploiting Gene-Environment Independence for Analysis of Case–Control Studies: An Empirical Bayes-Type Shrinkage Estimator to Trade-Off Between Bias and Efficiency
Mukherjee B, Chatterjee N. Exploiting Gene-Environment Independence for Analysis of Case–Control Studies: An Empirical Bayes-Type Shrinkage Estimator to Trade-Off Between Bias and Efficiency. Biometrics 2007, 64: 685-694. PMID: 18162111, DOI: 10.1111/j.1541-0420.2007.00953.x.Peer-Reviewed Original ResearchConceptsGene-environment independenceShrinkage estimatorsLog odds ratio parametersCase-control dataGene-environment independence assumptionOdds ratio parametersCase-control estimatorsData-adaptive fashionData exampleProspective logistic regression analysisBinary exposureGene-environment associationsIndependence assumptionLogistic regression analysisCase-onlyMaximum likelihood frameworkEstimationSample sizeBinary genesRegression analysisChatterjeeExamplesWeighted averageAssumptions
2006
Bayesian modeling for genetic association in case-control studies: accounting for unknown population substructure
Zhang L, Mukherjee B, Ghosh M, Wu R. Bayesian modeling for genetic association in case-control studies: accounting for unknown population substructure. Statistical Modelling 2006, 6: 352-372. DOI: 10.1177/1471082006071841.Peer-Reviewed Original ResearchPopulation substructureCase-control studyGenetic association studiesLog odds ratio parametersOdds ratio parametersAssociation studiesAllele frequenciesGenetic associationParametric Bayesian methodsArgentinean populationBayesian modelCredible intervalsGenetic factorsBayesian methodsStatistical propertiesNumerical integration techniquesPosterior probabilityAssociation modelPopulationAllelesGenesAssociationIntegration techniqueMarkovObesity