2020
Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis
Brown K, Diez-Roux A, Smith J, Needham B, Mukherjee B, Ware E, Liu Y, Cole S, Seeman T, Kardia S. Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis. Psychoneuroendocrinology 2020, 117: 104654. PMID: 32387875, PMCID: PMC7685527, DOI: 10.1016/j.psyneuen.2020.104654.Peer-Reviewed Original ResearchConceptsGene expressionMulti-Ethnic Study of AtherosclerosisGene set enrichment testGene Ontology databaseGene expression dataMulti-Ethnic StudyLifetime discriminationStudy of AtherosclerosisDifferential gene expressionInflammation-related genesExpression dataGene setsChronic burdenSocial factorsGene transcriptionRelated gene expressionOntology databaseGenesInflammatory responseTranscriptionGlobal analysisElastic net penalized regressionAdverse social factorsGlobal expressionExpression of inflammation-related genes
2015
Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis
Needham B, Smith J, Zhao W, Wang X, Mukherjee B, Kardia S, Shively C, Seeman T, Liu Y, Roux A. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics 2015, 10: 958-969. PMID: 26295359, PMCID: PMC4844216, DOI: 10.1080/15592294.2015.1085139.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisAssociated with DNA methylationSocioeconomic statusStress-related genesMulti-Ethnic StudyStudy of AtherosclerosisDNA methylationLow adult socioeconomic statusLife course socioeconomic statusLow childhood socioeconomic statusMeasures of socioeconomic statusAdult socioeconomic statusSocial patterning of diseaseChildhood socioeconomic statusGene expressionLow socioeconomic statusLife course measuresAssociated with gene expressionInflammation-related genesFunctional consequences of alterationsDNA methylation measurementsNon-HispanicHispanic participantsPotential functional consequencesEpigenetic data