2023
Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. Journal Of Reproductive Immunology 2023, 159: 103991. PMID: 37454540, PMCID: PMC10726844, DOI: 10.1016/j.jri.2023.103991.Peer-Reviewed Original ResearchConceptsBirth outcomesMatrix metalloproteinasesFetal sexPregnant womenFemale fetusesNewborn lengthVisit 3Associated with increased odds of preeclampsiaVisit 1Impact of matrix metalloproteinasesCustomized Luminex assayGestational diabetes mellitusOdds of preeclampsiaAdverse birth outcomesAssociated with increased oddsGestational ageHealthy pregnancyMale fetusesUterine remodelingLuminex assayLogistic regression modelsDiabetes mellitusStudy visitsInverse associationExtracellular matrix
2020
An efficient and computationally robust statistical method for analyzing case-control mother–offspring pair genetic association studies
Zhang H, Mukherjee B, Arthur V, Hu G, Hochner H, Chen J. An efficient and computationally robust statistical method for analyzing case-control mother–offspring pair genetic association studies. The Annals Of Applied Statistics 2020, 14: 560-584. DOI: 10.1214/19-aoas1298.Peer-Reviewed Original ResearchEnvironmental risk factorsRisk factorsMaternal environmental risk factorsOffspring genetic effectsPerinatal environmental risk factorsGenetic association studiesFinite sample performancePregnancy healthGenetic risk factorsAssessment of pre-Extensive simulation studyGestational diabetes mellitusIncreased statistical efficiencyLogistic regressionAssociation studiesMaternal genotypeSample performanceMendelian transmissionProfile likelihoodRegression modelsOffspring genotypesEarly-lifeInference proceduresLagrange multiplier methodLikelihood method