Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.
Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. The Journal Of Cardiovascular Surgery 1990, 31: 634-9. PMID: 2229164.Peer-Reviewed Original ResearchConceptsEndothelial cellsAdenylate cyclaseAdenylate cyclase activityEndothelial cell functionVascular endothelial cellsAortic endothelial cellsCultured endothelial cellsMembrane adenylate cyclaseTime-dependent increaseBovine aortic endothelial cellsHemodynamic changesCardiac outputRate of proliferationStretch receptorsCulture wellsPulsatile stretchingStatic culture techniquesPulsatile stressCrude membrane preparationsCyclase activityCell functionVascular biologySecretion of macromoleculesCyclasePulsatile nature