2007
The Role of the Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Cytokine System in Primary Hyperparathyroidism
Nakchbandi IA, Lang R, Kinder B, Insogna KL. The Role of the Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Cytokine System in Primary Hyperparathyroidism. The Journal Of Clinical Endocrinology & Metabolism 2007, 93: 967-973. PMID: 18073309, PMCID: PMC2266956, DOI: 10.1210/jc.2007-1645.Peer-Reviewed Original ResearchConceptsNuclear factor-kappaB ligandPrimary hyperparathyroidismBone lossReceptor activatorTotal femurIL-6Bone resorptionIL-6 soluble receptorMild primary hyperparathyroidismBone mineral densitySoluble receptor activatorMechanism of actionIL-6sRSRANKL levelsSerum levelsBone turnoverMineral densityCytokine systemSoluble receptorHyperparathyroidismNormal rangeSkeletal responsivenessBiochemical markersPatientsGreater risk
2002
Circulating Levels of Interleukin-6 Soluble Receptor Predict Rates of Bone Loss in Patients with Primary Hyperparathyroidism
Nakchbandi IA, Mitnick MA, Lang R, Gundberg C, Kinder B, Insogna K. Circulating Levels of Interleukin-6 Soluble Receptor Predict Rates of Bone Loss in Patients with Primary Hyperparathyroidism. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4946-4951. PMID: 12414855, DOI: 10.1210/jc.2001-011814.Peer-Reviewed Original ResearchConceptsBone lossIL-6sRTotal femurIL-6IL-6 soluble receptorPrimary hyperparathyroidism resultsYearly bone lossSubset of patientsUntreated hyperparathyroidismDisease activityPrimary hyperparathyroidismUpper tertileCytokine axisHyperparathyroidismSoluble receptorPatientsBiochemical markersClassical biochemical markersWhole groupFemurPredict rateGreater rateRecent studiesTertileGroup
1999
Inhibition of protein phosphatase 1 decreases PTH secretion from isolated dispersed parathyroid cells
Matovcik L, Rhee S, Schaefer J, da Cruz e Silva E, Kinder B. Inhibition of protein phosphatase 1 decreases PTH secretion from isolated dispersed parathyroid cells. Molecular And Cellular Endocrinology 1999, 154: 171-177. PMID: 10509811, DOI: 10.1016/s0303-7207(98)00224-x.Peer-Reviewed Original ResearchConceptsParathyroid hormone secretionOkadaic acidPP-1PP-1 activityPTH secretionPlasma membrane markerHormone secretionParathyroid cellsProtein phosphataseBasal PTH secretionTarget of inhibitionSubcellular fractionationPermeabilized cellsBovine cellsMembrane markersSecretory granulesIntact bovineIntact humanSecretionSelective inhibitorCellsPhosphataseOkadaicInhibitionMarkers
1997
Reconstitution of calcium-regulated parathyroid hormone secretion from streptolysin-O-permeabilized parathyroid cells by guanosine 5'-O-(thio)triphosphate.
Matovcik L, Rhee S, Schaefer J, Kinder B. Reconstitution of calcium-regulated parathyroid hormone secretion from streptolysin-O-permeabilized parathyroid cells by guanosine 5'-O-(thio)triphosphate. Endocrinology 1997, 138: 1170-9. PMID: 9048624, DOI: 10.1210/endo.138.3.4971.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCattleCell Membrane PermeabilityCyclic AMPCytosolEnergy MetabolismGuanine NucleotidesGuanosine 5'-O-(3-Thiotriphosphate)Osmolar ConcentrationParathyroid GlandsParathyroid HormoneParotid GlandStreptolysinsTime FactorsConceptsPTH secretionParathyroid cellsIntracellular Ca2Hormone secretionParathyroid hormone secretionGuanosine 5'Dose-dependent mannerCalcium/calmodulin-dependent protein kinase IIPTH releaseCalmodulin-dependent protein kinase IIExtracellular Ca2Physiological intracellular Ca2Protein kinase IISecretionAmbient Ca2Low Ca2Ca2GTPγSCellsInverse relationshipCytosolic cofactorsKinase IIAddition of GTPγSAbsence of GTPγSDependent regulation
1994
Endocrinology clinical case seminars: a 23-year-old man with hypercalcemia, anemia, and weight loss
Inzucchi SE, Chu P, Forman BH, Stewart AF, Kinder BK. Endocrinology clinical case seminars: a 23-year-old man with hypercalcemia, anemia, and weight loss. The Journal Of Clinical Endocrinology & Metabolism 1994, 79: 340-347. PMID: 8045945, DOI: 10.1210/jcem.79.2.8045945.Peer-Reviewed Original Research
1989
Expression of Transcripts Encoding a Parathyroid Hormone-Related Peptide in Abnormal Human Parathyroid Tissues*
IKEDA K, ARNOLD A, MANGIN M, KINDER B, VYDELINGUM N, BRENNAN M, BROADUS A. Expression of Transcripts Encoding a Parathyroid Hormone-Related Peptide in Abnormal Human Parathyroid Tissues*. The Journal Of Clinical Endocrinology & Metabolism 1989, 69: 1240-1248. PMID: 2573615, DOI: 10.1210/jcem-69-6-1240.Peer-Reviewed Original Research
1980
Diagnostic and Therapeutic Approaches to Primary Hyperparathyroidism
Kinder B, Broadus A, Lang R, Rasmussen H. Diagnostic and Therapeutic Approaches to Primary Hyperparathyroidism. Surgical Clinics Of North America 1980, 60: 1285-1295. PMID: 7434165, DOI: 10.1016/s0039-6109(16)42251-6.Peer-Reviewed Original ResearchMeSH KeywordsCalciumDihydroxycholecalciferolsHumansHyperparathyroidismMethodsParathyroid GlandsParathyroid Hormone