2024
Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study
Feizi A, DiRito J, Richfield O, Stendahl J, Harris M, Spindler S, Edwards C, Lysyy T, Lee S, Boutagy N, Feher A, Yoo P, Hosgood S, Mulligan D, Nicholson M, Sinusas A, Haakinson D, Tietjen G. Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study. Artificial Organs 2024 PMID: 39189738, DOI: 10.1111/aor.14840.Peer-Reviewed Original ResearchContrast-enhanced computed tomographyNormothermic perfusionComputed tomographyHuman kidneyLocal informationAnalysis of biopsiesAssess organ functionNovel therapeutic strategiesEx vivo assessmentWhole organ perfusionProof-of-concept studyEx vivo perfusionInfusion scansAnatomical structuresOrgan perfusionDeep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging
Shanbhag A, Miller R, Killekar A, Lemley M, Bednarski B, Van Kriekinge S, Kavanagh P, Feher A, Miller E, Bateman T, Liang J, Builoff V, Berman D, Dey D, Slomka P. Deep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging. Progress In Biomedical Optics And Imaging 2024, 12930: 129300b-129300b-6. DOI: 10.1117/12.3007914.Peer-Reviewed Original ResearchEpicardial adipose tissueUngated CTMyocardial infarctionEAT volumeRisk stratificationComputed tomographyEAT volume measurementEpicardial adipose tissue measurementsEpicardial adipose tissue volumeAssociated with risk of cardiovascular eventsRisk of cardiovascular eventsMedian follow-upIncreased risk of deathGated computed tomographyImprove risk stratificationAdipose tissue measurementsAssociated with riskRisk of deathAttenuation correction imagesGated CTChest CTNo significant differencePrognostic informationCardiovascular eventsFollow-up
2019
Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography
Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/circimaging.119.009063.Peer-Reviewed Original ResearchConceptsMicro-single photon emissionSingle photon emissionHindlimb ischemiaTomography/Tomography/Computed TomographyIschemic gastrocnemius muscleNIS inhibitor perchloratePeripheral artery diseaseSkeletal muscleUnilateral hindlimb ischemiaAdeno-Associated Virus Serotype 9Standardized uptake valueSodium/iodide symporterVivo quantificationVirus serotype 9Vivo validationNonischemic limbsArtery diseaseNonischemic muscleC57BL/6J miceMurine modelGastrocnemius muscleComputed tomographyIschemic conditionsRadiotracer uptake