2021
Wall shear stress estimated by 3D-QCA can predict cardiovascular events in lesions with borderline negative fractional flow reserve
Tufaro V, Safi H, Torii R, Koo BK, Kitslaar P, Ramasamy A, Mathur A, Jones DA, Bajaj R, Erdoğan E, Lansky A, Zhang J, Konstantinou K, Little CD, Rakhit R, Karamasis GV, Baumbach A, Bourantas CV. Wall shear stress estimated by 3D-QCA can predict cardiovascular events in lesions with borderline negative fractional flow reserve. Atherosclerosis 2021, 322: 24-30. PMID: 33706080, DOI: 10.1016/j.atherosclerosis.2021.02.018.Peer-Reviewed Original ResearchConceptsNegative fractional flow reserveCardiovascular eventsFractional flow reservePrimary endpointFlow reserveSmaller minimum lumen areaAdverse cardiovascular eventsRetrospective cohort studyTarget lesion revascularizationOnly independent predictorMinimum lumen areaQCA variablesAngiographic characteristicsLesion revascularizationCulprit lesionHighest maximum wall shear stressCohort studyCardiac deathIndependent predictorsComplete followMultivariable analysisMyocardial infarctionTarget lesionsArea stenosisNegative FFR
2013
Impact of bifurcation target lesion on angiographic, electrocardiographic, and clinical outcomes of patients undergoing primary percutaneous coronary intervention (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial).
Dudek D, Mehran R, Dziewierz A, Brener SJ, Rakowski T, Brzezinski M, Brodie BR, Xu K, Fahy M, Lansky AJ, Zmudka K, Stone GW. Impact of bifurcation target lesion on angiographic, electrocardiographic, and clinical outcomes of patients undergoing primary percutaneous coronary intervention (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial). EuroIntervention 2013, 9: 817-23. PMID: 24280158, DOI: 10.4244/eijv9i7a135.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionPrimary percutaneous coronary interventionCoronary interventionClinical outcomesTarget lesionsLow left ventricular ejection fractionPost-percutaneous coronary interventionLeft ventricular ejection fractionCore laboratory assessmentHigher contrast loadHORIZONS-AMI trialTarget vessel revascularisationProbable stent thrombosisST-segment resolutionElevation myocardial infarctionVentricular ejection fractionCore laboratory analysisRate of deathBTL groupHORIZONS-AMIVessel revascularisationInfarct arteryBaseline characteristicsContrast loadEvaluation of XIENCE V Everolimus-Eluting and Taxus Express2 Paclitaxel-Eluting Coronary Stents in Patients With Jailed Side Branches From the SPIRIT IV Trial at 2 Years
Forrest JK, Lansky AJ, Meller SM, Hou L, Sood P, Applegate RJ, Wang JC, Skelding KA, Shah A, Kereiakes DJ, Sudhir K, Cristea E, Yaqub M, Stone GW. Evaluation of XIENCE V Everolimus-Eluting and Taxus Express2 Paclitaxel-Eluting Coronary Stents in Patients With Jailed Side Branches From the SPIRIT IV Trial at 2 Years. The American Journal Of Cardiology 2013, 111: 1580-1586. PMID: 23499270, DOI: 10.1016/j.amjcard.2013.01.330.Peer-Reviewed Original ResearchConceptsSPIRIT IV trialMajor adverse cardiac eventsAdverse cardiac eventsClinical outcomesXIENCE VTarget lesionsCardiac eventsNovo native coronary artery lesionsIschemia-driven target vessel revascularizationTwo-year clinical outcomesNative coronary artery lesionsSPIRIT IIISide branchesXIENCE V EverolimusTarget lesion failureTarget vessel revascularizationCoronary artery lesionsPercutaneous coronary interventionSuperior clinical outcomesTreatment of patientsCoronary stent systemDrug-eluting stentsDiverse patient populationsEverolimus-ElutingSPIRIT IV
2008
A Novel Bioresorbable Polymer Paclitaxel-Eluting Stent for the Treatment of Single and Multivessel Coronary Disease Primary Results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II Study
Krucoff MW, Kereiakes DJ, Petersen JL, Mehran R, Hasselblad V, Lansky AJ, Fitzgerald PJ, Garg J, Turco MA, Simonton CA, Verheye S, Dubois CL, Gammon R, Batchelor WB, O'Shaughnessy CD, Hermiller JB, Schofer J, Buchbinder M, Wijns W, Group C. A Novel Bioresorbable Polymer Paclitaxel-Eluting Stent for the Treatment of Single and Multivessel Coronary Disease Primary Results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II Study. Journal Of The American College Of Cardiology 2008, 51: 1543-1552. PMID: 18420096, DOI: 10.1016/j.jacc.2008.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAngioplasty, Balloon, CoronaryAntineoplastic Agents, PhytogenicChromium AlloysClopidogrelCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDiabetes MellitusFemaleHumansMaleMiddle AgedPaclitaxelPlatelet Aggregation InhibitorsPolymersRiskThromboembolismTiclopidineTime FactorsConceptsPercutaneous coronary interventionTarget vessel revascularizationDrug-eluting stentsMajor adverse cardiac eventsMultivessel percutaneous coronary interventionTaxus drug-eluting stentsMyocardial infarctionAdjudicated deathAdverse cardiac eventsPrimary end pointSegment late lossSingle target lesionPre-specified subgroupsStent thrombosis ratesTreatment of SingleVessel revascularizationCardiac eventsCoronary interventionII studyThrombosis rateAngiographic analysisEpicardial vesselsTarget lesionsLate lossPatients
2004
Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz G, Dangas G, Lansky A, Aymong E, Negoita M, Fahy M, Moussa I, Roubin G, Moses J, Stone G, Leon M. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. DOI: 10.1583/1545-1550(2004)011<0060:iospad>2.0.co;2.Peer-Reviewed Original ResearchSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypassImpact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz GS, Dangas GD, Lansky AJ, Aymong ED, Negoita M, Fahy M, Moussa I, Roubin GS, Moses JW, Stone GW, Leon MB. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. PMID: 14748627, DOI: 10.1177/152660280401100108.Peer-Reviewed Original ResearchConceptsSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypass
2002
Retreatment immediately after gamma radiation for in-stent restenosis results in need for target vessel revascularization beyond target lesion
Hirose M, Kobayashi Y, Mehran R, Moussa I, Dangas G, Pop R, Adamian M, Collins M, Grise M, Lansky A, Mintz G, Stone G, Moses J, Leon M, Teirstein P. Retreatment immediately after gamma radiation for in-stent restenosis results in need for target vessel revascularization beyond target lesion. Journal Of The American College Of Cardiology 2002, 39: 65-66. DOI: 10.1016/s0735-1097(02)80283-2.Peer-Reviewed Original Research
2001
Acute and 6‐month clinical and angiographic outcome after implantation of the ACS Duet stent for single‐vessel coronary artery disease: Final results of the European and U.S. ACS Multi‐link Duet Registry
Foley D, Kererakes D, Riele J, Nishimura N, Veldhof S, Fink S, Yeung A, van Hoogenhuyze D, Lansky A, van Es G, Kutryk M, Serruys P. Acute and 6‐month clinical and angiographic outcome after implantation of the ACS Duet stent for single‐vessel coronary artery disease: Final results of the European and U.S. ACS Multi‐link Duet Registry. Catheterization And Cardiovascular Interventions 2001, 54: 25-33. PMID: 11553944, DOI: 10.1002/ccd.1233.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseSingle-vessel coronary artery diseaseMajor adverse cardiac eventsNative coronary artery lesionsObstructive coronary artery diseaseEffective percutaneous treatmentAdverse cardiac eventsCoronary artery lesionsProspective observational studyMinimum luminal diameterQuantitative coronary angiographyCoronary stent systemAdequate predilatationAngiographic outcomesArtery lesionsCardiac eventsCoronary angiographyPercutaneous treatmentRestenosis rateTarget lesionsLate outcomesLuminal diameterObservational studyStent systemLocalized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon M, Teirstein P, Moses J, Tripuraneni P, Lansky A, Jani S, Wong S, Fish D, Ellis S, Holmes D, Kerieakes D, Kuntz R. Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting. New England Journal Of Medicine 2001, 344: 250-256. PMID: 11172151, DOI: 10.1056/nejm200101253440402.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryBrachytherapyCombined Modality TherapyCoronary DiseaseCoronary ThrombosisDose-Response Relationship, RadiationDouble-Blind MethodFemaleGamma RaysHumansIridium RadioisotopesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsRadiotherapy DosageSecondary PreventionStentsConceptsIridium-192 groupMyocardial infarctionLate thrombosisStent restenosisIridium-192Intracoronary irradiationTarget lesionsIntracoronary gamma radiation therapyMajor adverse cardiac eventsFrequency of restenosisOral antiplatelet therapyAdverse cardiac eventsComposite of deathPrimary end pointLate myocardial infarctionIntracoronary radiation therapyIncidence of deathRecurrence of restenosisGamma radiation therapyEligible patientsAngiographic restenosisAntiplatelet therapyPlacebo groupCardiac eventsCoronary angioplasty
2000
Intracoronary brachytherapy not associated with changes in major side branches
Cottin Y, Lansky A, Kim H, Kollum M, Abrahimi A, Mehran R, Bhargava B, Chan R, Waksman R. Intracoronary brachytherapy not associated with changes in major side branches. Catheterization And Cardiovascular Interventions 2000, 51: 154-158. PMID: 11025567, DOI: 10.1002/1522-726x(200010)51:2<154::aid-ccd5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsSide branch occlusionMajor side branchesIntravascular radiationIntracoronary brachytherapyIrradiated groupSide branchesLate coronary occlusionTreatment of restenosisBaseline patientConsecutive patientsCoronary occlusionPatency ratesTotal occlusionSignificant stenosisLesion characteristicsTarget lesionsControl groupLow dosesPatientsAdverse effectsOcclusionHealing processSignificant decreaseStenosisRestenosis
1997
Comparison of Men Versus Women in Cross-Sectional Area Luminal Narrowing, Quantity of Plaque, Presence of Calcium in Plaque, and Lumen Location in Coronary Arteries by Intravascular Ultrasound in Patients with Stable Angina Pectoris
Kornowski R, Lansky A, Mintz G, Kent K, Pichard A, Satler L, Bucher T, Popma J, Leon M. Comparison of Men Versus Women in Cross-Sectional Area Luminal Narrowing, Quantity of Plaque, Presence of Calcium in Plaque, and Lumen Location in Coronary Arteries by Intravascular Ultrasound in Patients with Stable Angina Pectoris. The American Journal Of Cardiology 1997, 79: 1601-1605. PMID: 9202348, DOI: 10.1016/s0002-9149(97)00206-3.Peer-Reviewed Original ResearchConceptsExternal elastic membraneIntravascular ultrasoundCoronary atherosclerosisPlaque burdenCross-sectional area luminal narrowingPreinterventional intravascular ultrasoundNative coronary lesionsStable angina pectorisMen Versus WomenProximal reference siteBody surface areaComorbid clinical conditionsQuantity of plaqueChronic anginaCoronary interventionAngina pectorisCoronary lesionsLuminal narrowingCoronary arteryIVUS analysisPlaque eccentricityTarget lesionsIVUS measuresClinical conditionsM area