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Mental Health & Behavioral Research, Phase Pilot

AMPA Receptor Components of the Anti-Depressant Ketamine Response

What is the purpose of this trial?

Looking for adults experiencing depression to participate in paid MRI research

Are you currently experiencing severe depression? Have you tried antidepressants before without success? Would you like to participate in a research study? Help us understand the effects of the rapid antidepressant ketamine on the brain and earn up to

$720 compensation for your time.

Study involves:

  • A physical examination
  • Providing blood for genetic analysis
  • Thinking tasks
  • Receiving ketamine as an experimental treatment for your depression
  • Taking a study drug that may change the effects of the ketamine or your depressive symptoms
  • Up to 4 MRI scans
  • Speaking on the phone with study staff about how you are feeling after receiving ketamine

Participants must be:

  • 18-60 years of age
  • Right-handed
  • Currently experiencing severe depression
  • Have tried at least one antidepressant treatment in the past
  • Willing to abstain from using recreational drugs and alcohol for 1 week before each MRI scan

Participants must NOT:

  • Have metal in their body that prevents them from getting an MRI scan
  • Be currently abusing drugs or alcohol

If you have not received ketamine as a treatment for depression, we will ask you to try ketamine in an outpatient hospital setting for additional compensation.

For more information and to find out if you are eligible, please contact Leslie Maldonado at nempro.lab@yale.edu or call (203) 508-7787.

  • Trial with
    Yale University School of Medicine, National Institute of Mental Health (NIMH), and National Center for PTSD (NCPTSD)
  • Ages
    18 years - 65 years
  • Gender
    Both

Contact Information

For more information about this study, including how to volunteer, contact Leslie Maldonado

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

  • Last Updated
    10/16/2024
  • Study HIC
    #2000021345