2024
Stability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bandsOptimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data
Iktimal A, Spencer D, Alkawadri R. Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data. Annals Of Neurology 2024, 96: 187-193. PMID: 38506405, DOI: 10.1002/ana.26915.Peer-Reviewed Original ResearchMultilayer perceptronTanh activation functionArea under the curveMultilayer Perceptron performanceOptimal multilayer perceptronImbalanced dataF1 scoreFeature extensionNeural networkActivation functionElectroencephalogram-dataSensorimotor cortexIntractable epilepsy patientsPerceptronCentral sulcusCross-validationAnterior lipEpilepsy patientsGaussian distribution functionFunctional mappingNetworkMetrics
2006
Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activity