2015
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metabolism 2015, 22: 936-947. PMID: 26411341, PMCID: PMC4635072, DOI: 10.1016/j.cmet.2015.08.021.Peer-Reviewed Original Research
2014
Glutamate Metabolism in Major Depressive Disorder
Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate Metabolism in Major Depressive Disorder. American Journal Of Psychiatry 2014, 171: 1320-1327. PMID: 25073688, PMCID: PMC4472484, DOI: 10.1176/appi.ajp.2014.14010067.Peer-Reviewed Original Research
2010
Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR
Patel AB, de Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR. Cerebrovascular And Brain Metabolism Reviews 2010, 30: 1200-1213. PMID: 20125180, PMCID: PMC2879471, DOI: 10.1038/jcbfm.2010.2.Peer-Reviewed Original Research
2006
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose
Mason GF, Petersen KF, De Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose. Journal Of Neurochemistry 2006, 100: 73-86. PMID: 17076763, PMCID: PMC2995551, DOI: 10.1111/j.1471-4159.2006.04200.x.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexCerebral cortexArterial-venous differencesAwake humansNeurotransmitter cyclingGlutamine effluxNeurotransmitter traffickingOccipital-parietal regionsGlutamateCortexPyruvate carboxylase fluxRecent studiesGlutamine synthesisPyruvate carboxylaseMagnetic resonance spectroscopyMost studiesGlutaminePyruvate dehydrogenase
2001
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle fluxDifferential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro
Novotny E, Ariyan C, Mason G, O’Reilly J, Haddad G, Behar K. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Research 2001, 888: 193-202. PMID: 11150475, DOI: 10.1016/s0006-8993(00)03051-1.Peer-Reviewed Original ResearchConceptsGlucose oxidative metabolismNeocortical slicesOxidative metabolismRat postnatal developmentCortical glutamateCerebral cortexCortex maturesPostnatal dayPostnatal developmentAge groupsCortexMitochondrial TCA cycleGreater increaseVivoGlucose oxidationTCA cycle fluxDifferential increaseAcid extractsMetabolismSlicesDeafferentiationCycle fluxRats
1999
Measurement of the Tricarboxylic Acid Cycle Rate in Human Grey and White Matter in Vivo by 1H-[13C] Magnetic Resonance Spectroscopy at 4.1T
Mason G, Pan J, Chu W, Newcomer B, Zhang Y, Orr R, Hetherington H. Measurement of the Tricarboxylic Acid Cycle Rate in Human Grey and White Matter in Vivo by 1H-[13C] Magnetic Resonance Spectroscopy at 4.1T. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 1179-1188. PMID: 10566964, DOI: 10.1097/00004647-199911000-00002.Peer-Reviewed Original ResearchDetermination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
Shen J, Petersen K, Behar K, Brown P, Nixon T, Mason G, Petroff O, Shulman G, Shulman R, Rothman D. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8235-8240. PMID: 10393978, PMCID: PMC22218, DOI: 10.1073/pnas.96.14.8235.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cycleGlutamine cycleCerebral cortexMin/Rat cerebral cortexVivo 13C NMR spectraGlucose oxidation ratesHuman brainGlucose oxidationGlutamatergic activityRat modelTricarboxylic acid cycle rateParietal lobeHuman cortexCortexTime courseBrainGlutamine synthesisMajor metabolic fluxCycle rateTricarboxylic acid cycleHigh levelsInfusionRatsAcid cycle
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo results
1997
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling
Sibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.Peer-Reviewed Original Research13C editing of glutamate in human brain using J‐refocused coherence transfer spectroscopy at 4.1 T
Pan J, Mason G, Vaughan J, Chu W, Zhang Y, Hetherington H. 13C editing of glutamate in human brain using J‐refocused coherence transfer spectroscopy at 4.1 T. Magnetic Resonance In Medicine 1997, 37: 355-358. PMID: 9055224, DOI: 10.1002/mrm.1910370308.Peer-Reviewed Original Research
1996
The13C isotope and nuclear magnetic resonance: unique tools for the study of brain metabolism
Mason G, Behar K, Lai J. The13C isotope and nuclear magnetic resonance: unique tools for the study of brain metabolism. Metabolic Brain Disease 1996, 11: 283-313. PMID: 8979250, DOI: 10.1007/bf02029492.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose
Gruetter R, Novotny E, Boulware S, Mason G, Rothman D, Shulman G, Prichard J, Shulman R. Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose. Journal Of Neurochemistry 1994, 63: 1377-1385. PMID: 7931289, DOI: 10.1046/j.1471-4159.1994.63041377.x.Peer-Reviewed Original Research
1993
Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance
Gruetter R, Novotny E, Boulware S, Rothman D, Mason G, Shulman G, Tamborlane W, Shulman R. Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance. Advances In Experimental Medicine And Biology 1993, 331: 35-40. PMID: 8333347, DOI: 10.1007/978-1-4615-2920-0_7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseBlood-Brain BarrierBrainCarbon IsotopesGlucoseHumansMagnetic Resonance SpectroscopyRat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy
Mason G, Behar K, Martin M, Shulman R. Rat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy. Advances In Experimental Medicine And Biology 1993, 331: 29-34. PMID: 8333345, DOI: 10.1007/978-1-4615-2920-0_6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportBrainCarbon IsotopesGlucoseKineticsMagnetic Resonance SpectroscopyMaleRatsRats, Sprague-Dawley
1992
NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original ResearchNMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain
Mason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.Peer-Reviewed Original Research