2024
Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, Miller C, Bredael G, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array. NMR In Biomedicine 2024, 37: e5195. PMID: 38845018, DOI: 10.1002/nbm.5195.Peer-Reviewed Original ResearchStimulated echo acquisition modeSignal-to-noise ratioSlice-selective excitationAdiabatic selective refocusingUltra-high fieldIncreased spectral dispersionEcho acquisition modeSpectral dispersionVoxel positionSemi-localPhantomAcquisition modeElectromagnetic simulationsHuman brainSAR limitsExcitationBi-frontalSLASERHealthy volunteersSpectra
2023
Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion
Ahmadian N, Jacobs S, Gosselink M, van der Kemp W, Hoogduin H, Coppoli A, Mason G, de Graaf R, Norouzizadeh H, Mahon C, van Marle S, van Eijsden P, Cerneus D, Miller C, De Lepeleire I, Basile A, Klomp D, Prompers J, Wiegers E. Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/5332.Peer-Reviewed Original Research
2017
The human brain produces fructose from glucose
Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.Peer-Reviewed Original ResearchConceptsPolyol pathwayFructose levelsIntracerebral glucoseBlood-brain barrierPathogenesis of obesityType 2 diabetesEffects of fructoseHuman brainRegression model analysisCNS deliveryCNS effectsHyperglycemic clampHealthy subjectsDietary consumptionGlucoseBaselineBrainMixed-effects regression model analysisFeeding behaviorMinutesCN productionObesityDiabetesLevelsPathogenesis
1999
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
Shen J, Petersen K, Behar K, Brown P, Nixon T, Mason G, Petroff O, Shulman G, Shulman R, Rothman D. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8235-8240. PMID: 10393978, PMCID: PMC22218, DOI: 10.1073/pnas.96.14.8235.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cycleGlutamine cycleCerebral cortexMin/Rat cerebral cortexVivo 13C NMR spectraGlucose oxidation ratesHuman brainGlucose oxidationGlutamatergic activityRat modelTricarboxylic acid cycle rateParietal lobeHuman cortexCortexTime courseBrainGlutamine synthesisMajor metabolic fluxCycle rateTricarboxylic acid cycleHigh levelsInfusionRatsAcid cycle
1996
Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation
Hetherington H, Pan J, Mason G, Adams D, Vaughn M, Twieg D, Pohost G. Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magnetic Resonance In Medicine 1996, 36: 21-29. PMID: 8795016, DOI: 10.1002/mrm.1910360106.Peer-Reviewed Original Research
1994
Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose
Gruetter R, Novotny E, Boulware S, Mason G, Rothman D, Shulman G, Prichard J, Shulman R. Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose. Journal Of Neurochemistry 1994, 63: 1377-1385. PMID: 7931289, DOI: 10.1046/j.1471-4159.1994.63041377.x.Peer-Reviewed Original Research