1987
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
Vaccarino F, Guidotti A, Costa E. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 8707-8711. PMID: 2825205, PMCID: PMC299615, DOI: 10.1073/pnas.84.23.8707.Peer-Reviewed Original ResearchConceptsGranule cellsProtein kinase C translocationExcitatory amino acid neurotransmitter receptorsAmino acid neurotransmitter receptorsPrimary culturesGlutamate-mediated Ca2Cerebellar granule cellsHigh affinity recognition sitesPKC translocationNeurotransmitter receptorsRemoval of Ca2Cerebellar neuronsActivation of PKCC translocationNeuronal membranesGanglioside inhibitionRedistribution of PKCIncubation mediumGlutamateCa2PKCActivation
1985
GABA‐Modulin: A Synaptosomal Basic Protein that Differs from Small Myelin Basic Protein of Rat Brain
Vaccarino F, Tronconi B, Panula P, Guidotti A, Costa E. GABA‐Modulin: A Synaptosomal Basic Protein that Differs from Small Myelin Basic Protein of Rat Brain. Journal Of Neurochemistry 1985, 44: 278-290. PMID: 3964832, DOI: 10.1111/j.1471-4159.1985.tb07142.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsBrain ChemistryCarrier ProteinsChromatography, High Pressure LiquidCyanogen BromideGABA Plasma Membrane Transport ProteinsMembrane ProteinsMembrane Transport ProteinsMuscimolMyelin ProteinsMyelin SheathNerve Tissue ProteinsOrganic Anion TransportersPeptide FragmentsRatsSubcellular FractionsSynaptosomesTissue DistributionConceptsGABA-modulinSmall myelin basic proteinMyelin basic proteinRat brainBasic proteinModulation of GABANeuronal membrane functionNeurotransmitter receptorsSynaptosomal fractionGABA bindingSynaptic membranesSynaptosomal membranesStaphylococcal V8 protease digestionSynaptosomal proteinsNeuronal specificityAcid compositionHigh potencyGABAHigh-affinity bindingBrainMyelinAmino acid compositionTotal synaptosomal proteinApparent molecular weightMembrane function