2011
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Nicotine Decreases Food Intake Through Activation of POMC Neurons. Science 2011, 332: 1330-1332. PMID: 21659607, PMCID: PMC3113664, DOI: 10.1126/science.1201889.Peer-Reviewed Original ResearchConceptsFood intakePOMC neuronsNicotine decreases food intakeDecrease food intakePro-opiomelanocortin (POMC) neuronsΑ3β4 nicotinic acetylcholine receptorsHypothalamic melanocortin systemNicotine-induced decreasesMelanocortin-4 receptorNicotinic acetylcholine receptorsAnorexic effectDecrease appetiteSmoking cessationSynaptic mechanismsMelanocortin systemNovel treatmentsBody weightAcetylcholine receptorsNeurobiological mechanismsNeuronsIntakeSubsequent activationAppetiteActivationReceptors
2010
Galanin and Addiction
Picciotto MR. Galanin and Addiction. EXS 2010, 102: 195-208. PMID: 21299070, DOI: 10.1007/978-3-0346-0228-0_14.Peer-Reviewed Original ResearchConceptsGalanin receptorsFood intakeOpiate rewardDrug rewardAbility of neuropeptidesMesolimbic dopamine systemDrugs of abuseGalanin agonistsNoradrenergic neuronsDrug withdrawalStriatal slicesWithdrawal signsAnalgesic propertiesLocus coeruleusHypothalamic functionDopamine releaseGalaninDopamine systemNovel treatmentsPlace preferenceStress-related pathwaysFiring ratePotential targetWithdrawalIntake
2008
Galanin – 25 years with a multitalented neuropeptide
Picciotto MR. Galanin – 25 years with a multitalented neuropeptide. Cellular And Molecular Life Sciences 2008, 65: 1872-1879. PMID: 18500649, PMCID: PMC11131873, DOI: 10.1007/s00018-008-8151-x.Peer-Reviewed Original ResearchConceptsGalanin receptorsFood intakeOpiate rewardDrug rewardGalanin – 25 yearsAbility of neuropeptidesMesolimbic dopamine systemDrugs of abuseGalanin agonistsNoradrenergic neuronsDrug withdrawalStriatal slicesWithdrawal signsAnalgesic propertiesLocus coeruleusHypothalamic functionDopamine releaseDopamine systemGalaninNovel treatmentsPlace preferenceStress-related pathwaysFiring ratePotential targetWithdrawal
1998
Nicotine Addiction: From Molecules to Behavior
Picciotto M. Nicotine Addiction: From Molecules to Behavior. The Neuroscientist 1998, 4: 391-394. DOI: 10.1177/107385849800400610.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNicotine addictionAction of nicotineNicotinic acetylcholine receptorsBinding of nicotineDrugs of abuseUnique molecular targetNicotine dependenceNovel treatmentsAcetylcholine receptorsDopamine physiologyMolecular targetsCommon pathwayNicotineBrainSite of interventionNeurobiological processesBiochemical targetsAddictionDrugsPathwaySmokingMiceReceptors