2025
A genetically informed brain atlas for enhancing brain imaging genomics
Bao J, Wen J, Chang C, Mu S, Chen J, Shivakumar M, Cui Y, Erus G, Yang Z, Yang S, Wen Z, Zhao Y, Kim D, Duong-Tran D, Saykin A, Zhao B, Davatzikos C, Long Q, Shen L. A genetically informed brain atlas for enhancing brain imaging genomics. Nature Communications 2025, 16: 3524. PMID: 40229250, PMCID: PMC11997130, DOI: 10.1038/s41467-025-57636-6.Peer-Reviewed Original ResearchConceptsBrain imaging genomicsImaging genomicsComplex traits/diseasesSNP heritabilityFunctional annotationGenetic architecturePolygenic risk scoresGenomic investigationsGenetic ancestryDiscovery powerBrain atlasesHuman brain structureGenetic determinantsNeuroanatomical heterogeneityGenomeNeuroanatomical variationImaging endophenotypesBrain structuresMolecular levelBrain voxelsHeritabilityPhenotypic correlationsGiant regionGeneticsBrain conditions
2021
Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
Yingxuan E, Yao X, Liu K, Risacher SL, Saykin AJ, Long Q, Zhao Y, Shen L. Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes. AMIA Annual Symposium Proceedings 2021, 2020: 422-431. PMID: 33936415, PMCID: PMC8075527.Peer-Reviewed Original Research
2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease
Freeze B, Acosta D, Pandya S, Zhao Y, Raj A. Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease. NeuroImage Clinical 2018, 18: 456-466. PMID: 29868450, PMCID: PMC5984599, DOI: 10.1016/j.nicl.2018.01.009.Peer-Reviewed Original ResearchConceptsRegional brain atrophyProgression Markers InitiativeBrain atrophyRegional atrophyParkinson's Progression Markers InitiativeMultivariable regression analysisSignificant predictorsHigh-resolution magnetic resonanceParkinson's disease pathogenesisAutosomal recessive PDPD-related genesRegional expressionResolution magnetic resonanceBrain atlasParkinson's diseaseRegional dysfunctionDisease pathogenesisAtrophyGenetic predictorsTop candidate genesExpression patternsAllen Brain AtlasRegression analysisPredictorsMagnetic resonance
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