2025
Semiparametric joint modeling for biomarker trajectory before disease onset
Sun Y, Zhao X, Chan K, Xu W, Allore H, Zhao Y. Semiparametric joint modeling for biomarker trajectory before disease onset. Biometrics 2025, 81: ujaf064. PMID: 40433774, PMCID: PMC12117339, DOI: 10.1093/biomtc/ujaf064.Peer-Reviewed Original ResearchConceptsSemiparametric joint modelFinite-sample performanceLarge-sample propertiesConduct simulation studiesBiomarker trajectoriesNatural time scaleJoint modelEstimated regression coefficientsTime-on-studySimulation studyTrajectory functionRegression coefficientsEquationsKernelTime scalesProfile kernel
2024
Topology-based Clustering of Functional Brain Networks in an Alzheimer's Disease Cohort.
Xu F, Gao M, Chen J, Garai S, Duong-Tran D, Zhao Y, Shen L. Topology-based Clustering of Functional Brain Networks in an Alzheimer's Disease Cohort. AMIA Joint Summits On Translational Science Proceedings 2024, 2024: 449-458. PMID: 38827100, PMCID: PMC11141857.Peer-Reviewed Original ResearchFunctional brain networksDistance kernelBrain networksUnsupervised clustering techniquesMedial temporal lobeMachine learning methodsTopology-based clusteringSpectral clusteringClustering algorithmClustering techniqueLearning methodsAlzheimer's disease cohortProgressive neurodegenerative diseaseNetwork neuroscienceFunctional MRI modalitiesFunctional topologyAlzheimer's diseaseNeurodegenerative diseasesWhole-brain phenomenonNetworkBrain functional topologyKernelInvestigate variationsAlzheimerFunctional connectivity
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