The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation
Joo Y, Parrado C, Li W, Yang R, Black E, Bleichert F, Liu Y, Kabeche L. The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation. Cell Reports 2025, 44: 116019. PMID: 40705605, PMCID: PMC12451630, DOI: 10.1016/j.celrep.2025.116019.Peer-Reviewed Original ResearchConceptsDNA damage responseCdk1 activityATR-Chk1 pathwayChromosome segregationATR-Chk1Aurora B activityResidual activityCheckpoint kinase 1Mitotic progressionCDK1 inhibitionDamage responseRad3-relatedCDK1Lagging chromosomesATR-Chk1 activationHuman cellsChromosomeKinase 1Ataxia telangiectasiaMitosisChk1DNA damageDNAB activityPartial loss
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