Timothy Hsiao
he/him/his
Postgraduate AssociateAbout
Research
Publications
2025
Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles
Liu Y, Wang X, Krishnan N, Hsiao T, Ji Y, Kaneko K, Teneche M, Adams P, Zuniga E, Kaech S, Zhang L, Feng G. Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles. Hepatology 2025, 84: 424-439. PMID: 40928035, PMCID: PMC13242308, DOI: 10.1097/hep.0000000000001514.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsAPD-L1Liver tumorsLipid nanoparticlesTumor-suppressive effectsSingle doseCD8+ T cell infiltrationAnti-PD-L1 antibodyLiver cancerAssociated with several adverse effectsAnti-PD-L1T cell infiltrationMetastatic liver tumorsMechanism-based therapeutic agentsHepatic immune microenvironmentType I Interferon SignalingLiver tumor modelLiver tumor progressionLiver-targeting strategiesSevere adverse effectsI interferon signalingEfficacious monotherapyCheckpoint inhibitorsAntitumor immunityAntitumor response
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Yale School of Medicine
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