About
Titles
Associate Dean, Digital Strategy & Transformation, Office of the Dean, YSM; Professor in Biomedical Informatics & Data Sciences, YSM; Professor of Neurology, YSM; Senior Vice President & Chief Digital Health Officer, YNHHS
Biography
Dr. Lee H. Schwamm, MD is Associate Dean for Digital Strategy and Transformation for Yale School of Medicine, and Senior Vice President + Chief Digital Health Officer for Yale New Haven Health System. In this role, he is leading the development of a new digital health strategy for the school and the health system, and serves as an influential physician leader and an agent of change to catalyze the equitable adoption of virtual care and digital enablement throughout the enterprise.
Before joining Yale, Dr. Schwamm spent 3 decades of service at the Mass General Brigham Health System in academic and administrative leadership roles. He was the inaugural C. Miller Fisher Chair in Vascular Neurology, Executive Vice Chair of Neurology and Director of the Center for TeleHealth at Massachusetts General Hospital; Vice President for Digital Patient Experience and Virtual Care, and Chief Digital Advisor for the Mass General Brigham Health System, and a Professor of Neurology at Harvard Medical School. He oversaw all systemwide virtual care and telehealth activities including synchronous and synchronous virtual visits and consults, remote patient monitoring, virtual urgent care and online second opinions. During the first 6 months of COVID, he led adoption efforts for 10,000 clinicians to provide over 1.7 M virtual visits, and introduced a suite of innovative inpatient virtual solutions.
A graduate of both Harvard College and Harvard Medical School, he completed residency training in neurology, and fellowship training in stroke and neurocritical care, all at Massachusetts General Hospital where he subsequently joined the faculty in 1996. He has spent the past 2 decades in telehealth, as a pioneer in telestroke and a leading advocate and policy advisor for the American Heart Association. He is a an internationally recognized expert in stroke diagnosis, treatment and prevention and a Fellow of the American Heart Association, American Academy of Neurology and the American Neurological Association. His research has been funded by many organizations including the NIH, AHA, PCORI, AHRQ, HRSA, CDC, and others, and he is the author of >500 peer-reviewed articles and chaired many of the current practice guidelines for stroke and telehealth-enabled care delivery. Under his leadership, the AHA Get with the Guidelines–Stroke Registry has grown into the world’s largest stroke registry with over 8M patient encounters; it has changed stroke practice at hospitals across the US, and set a global standard for stroke care. He has received numerous awards for innovation, leadership, and advocacy in the field of stroke and digital health, and held many senior leadership positions within the AHA, including service on their National Board of Directors. He has served on multiple editorial boards, including the digital health section editor for Stroke, and the international advisory board for Lancet Digital Health.
Appointments
Office of the Dean, School of Medicine
Associate DeanDualBiomedical Informatics & Data Science
ProfessorSecondaryNeurology
ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Digital Technology Solutions Leadership
- Neurology
- Office of the Dean, School of Medicine
- Virtual Care Consensus
- Yale Medicine
Education & Training
- Fellowship
- Massachusetts General Hospital (1996)
- Residency
- Massachusetts General Hospital (1995)
- Internship
- Beth Israel Hospital (1992)
- MD
- Harvard Medical School, Medicine (1991)
- AB
- Harvard University, Philosophy (1985)
Research
Publications
2025
Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke
Sun S, Lomachinsky V, Smith L, Newhouse J, Westover M, Blacker D, Schwamm L, Haneuse S, Moura L. Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke. Neurology Clinical Practice 2025, 15: e200452. PMID: 40144887, DOI: 10.1212/cpj.0000000000200452.Peer-Reviewed Original ResearchFall-related injuriesRisk of fallsOlder adultsAcute ischemic strokeRisk differenceAcute ischemic stroke admissionsElectronic health recordsHypothetical randomized trialInverse probability weightingIschemic strokeRecovery periodHealth recordsBenzodiazepine initiationPoststroke periodConfounding biasImmortal timeMild strokeBenzodiazepine prescriptionsBZD useDay of admissionProbability weightingSubgroup analysisAnalyzed dataStrokeAdultsEfficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.
Shiomi Y, Miwa K, Jensen M, Inoue M, Yoshimura S, Kamogawa N, Fukuda-Doi M, Ma H, Ringleb P, Wu O, Schwamm L, Davis S, Donnan G, Gerloff C, Nakahara J, Toyoda K, Thomalla G, Koga M. Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data. International Journal Of Stroke 2025, 17474930251322034. PMID: 39921231, DOI: 10.1177/17474930251322034.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhagePrevalence of vascular risk factorsIntravenous alteplaseSafety of intravenous alteplaseIndividual participant dataEffect of intravenous alteplaseControl groupVascular risk factorsRandomized controlled trialsRisk of symptomatic intracranial hemorrhageDays post-strokeRate of symptomatic intracranial hemorrhagePost-strokeAlteplase groupAntiplatelet therapy groupParticipant dataSafety outcomesAntiplatelet therapyStroke thrombolysisAntiplatelet therapy patientsControlled trialsBaseline dataModified Rankin Scale scoreFavorable outcomeRisk factorsEffects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials.
Fukuda-Doi M, Koga M, Thomalla G, Jensen M, Inoue M, Yoshimura S, Miwa K, Gerloff C, Davis S, Donnan G, Ma H, Hacke W, Ringleb P, Wu O, Schwamm L, Warach S, Toyoda K. Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials. European Stroke Journal 2025, 23969873241309512. PMID: 39749428, PMCID: PMC11696941, DOI: 10.1177/23969873241309512.Peer-Reviewed Original ResearchFavorable outcomeIntravenous thrombolysisPooled analysis of individual patient-level dataPooled analysisClinical trialsBaseline National Institutes of Health Stroke Scale scoreSex-based differencesPooled analysis of clinical trialsIschaemic strokeNational Institutes of Health Stroke Scale scoreSevere clinical statusIndividual patient-level dataStroke Scale scorePatient-level dataAnalysis of clinical trialsOrdinal regression modelAtrial fibrillationPatient sexClinical statusMultivariable adjustmentFemale sexThrombolysis trialsOnset timePrimary outcomeFunctional outcomes
2024
Mobile Stroke Unit Management in Patients With Acute Ischemic Stroke Eligible for Intravenous Thrombolysis
Mac Grory B, Sun J, Alhanti B, Lusk J, Li F, Adeoye O, Furie K, Hasan D, Messe S, Sheth K, Schwamm L, Smith E, Bhatt D, Fonarow G, Saver J, Xian Y, Grotta J. Mobile Stroke Unit Management in Patients With Acute Ischemic Stroke Eligible for Intravenous Thrombolysis. JAMA Neurology 2024, 81: 1250-1262. PMID: 39466286, PMCID: PMC11581552, DOI: 10.1001/jamaneurol.2024.3659.Peer-Reviewed Original ResearchEmergency medical servicesEmergency medical service managementMobile stroke unitPrehospital managementSymptomatic intracranial hemorrhageHospital dischargeGlobal disabilityIn-hospital mortalityEfficacy end pointUtility-weighted modified Rankin scaleStroke unit managementAcute ischemic strokeIschemic strokePrimary analytic cohortDiagnosis of ischemic strokeIntravenous thrombolysisAmerican Heart AssociationEnd pointsGuidelines-StrokeUW-mRSSecondary efficacy end pointsMain OutcomesMedical servicesStroke unitAmbulation statusCare Quality and Outcomes of Ischemic Stroke in Patients With Premorbid Dementia: Get With The Guidelines-Stroke Registry
Ganesh A, Wang M, Schwamm L, Fonarow G, Messé S, Xian Y, Saver J, Smith E. Care Quality and Outcomes of Ischemic Stroke in Patients With Premorbid Dementia: Get With The Guidelines-Stroke Registry. Stroke 2024, 55: 2901-2905. PMID: 39503052, DOI: 10.1161/strokeaha.124.049027.Peer-Reviewed Original ResearchQuality of stroke carePremorbid dementiaGuidelines-Stroke registryStroke careGuidelines-StrokeDoor-to-needle timeImprove care qualityNational quality measuresQuality of careEmergency medical servicesQuality measuresHospice admissionPrestroke dementiaCare qualityDementia diagnosisIschemic strokeAcute stroke interventionHospital characteristicsIntravenous thrombolysisDischarge destinationPoststroke outcomesMedical servicesIn-hospital mortalityIschemic stroke patientsComprehensive stroke centerLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsTwenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program
Xian Y, Li S, Jiang T, Beon C, Poudel R, Thomas K, Reeves M, Smith E, Saver J, Sheth K, Messé S, Schwamm L, Fonarow G. Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program. Stroke 2024, 55: 2599-2610. PMID: 39429153, PMCID: PMC11518659, DOI: 10.1161/strokeaha.124.048174.Peer-Reviewed Original ResearchConceptsGuidelines-Stroke programEvidence-based stroke careDoor-to-needle timeTransient ischemic attackGuidelines-Stroke hospitalsEvidence-based careQuality of careSmoking cessation counselingSustained improvementQuality improvement initiativesSkilled nursing facilityIndependence of patientsAcute ischemic strokeIschemic strokeRelevant to patientsIschemic attackDoor-to-puncture timeCessation counselingGuidelines-StrokeAssociated with sustained improvementStroke careDysphagia screeningNursing facilitiesHospital characteristicsImprovement initiativesBenzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends
Torres V, Brooks J, Donahue M, Sun S, Hsu J, Price M, Blacker D, Schwamm L, Newhouse J, Haneuse S, Moura L. Benzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends. Stroke 2024, 55: 2694-2702. PMID: 39417222, PMCID: PMC11729356, DOI: 10.1161/strokeaha.124.047257.Peer-Reviewed Original ResearchConceptsIschemic stroke dischargesSkilled nursing facilityDays supplyMonths prior enrollmentUS Medicare claimsIschemic stroke survivorsPost-acute ischemic strokeIschemic strokeNursing facilitiesStroke survivorsStroke dischargesMedicare claimsBenzodiazepine initiationTraditional Medicare coverageMedicare coverageMedical insuranceBenzodiazepine prescriptionsExamined demographicsAcute ischemic strokeInitiation rateLongitudinal trendsPrescription patternsPart AHospital insurancePrescriptionClinically relevant findings on 24-h head CT after acute stroke therapy: The 24-h CT score
Zhang B, King A, Voetsch B, Silverman S, Schwamm L, Ji X, Singhal A. Clinically relevant findings on 24-h head CT after acute stroke therapy: The 24-h CT score. International Journal Of Stroke 2024, 20: 226-234. PMID: 39324561, DOI: 10.1177/17474930241289992.Peer-Reviewed Original ResearchCT scoreCT findingsHead CTClinically relevant findingsFollow-up head CTRoutine head computed tomographyHead CT findingsHead computed tomographyConsecutive acute ischemic stroke patientsBlood pressure goalsAcute ischemic stroke patientsLow-risk groupMedium-risk groupAdministration of mannitolHigh-risk groupMultivariate logistic regressionAcute stroke therapyComprehensive stroke centerIschemic stroke patientsBlood glucose levelsCT abnormalitiesAntithrombotic treatmentRelevant findingsHypertonic salineRetrospective studyEvaluating the concordance between International Classification of Diseases, Tenth Revision Code and stroke severity as measured by the National Institutes of Health Stroke Scale
Taha M, Habib M, Lomachinsky V, Hadar P, Newhouse J, Schwamm L, Blacker D, Moura L. Evaluating the concordance between International Classification of Diseases, Tenth Revision Code and stroke severity as measured by the National Institutes of Health Stroke Scale. BMJ Neurology Open 2024, 6: e000831. PMID: 39363950, PMCID: PMC11448239, DOI: 10.1136/bmjno-2024-000831.Peer-Reviewed Original ResearchPaul Coverdell National Acute Stroke ProgramNational Institutes of Health Stroke ScaleInternational Classification of DiseasesClassification of DiseasesHealth Stroke ScaleInternational ClassificationICD-10Acute ischaemic strokeStroke severityICD-10 diagnosis codesStroke ScaleNIHSS scoreMeasures of stroke severityMedicare claims dataIntraclass correlation coefficientNational Institutes of Health Stroke Scale scoreNational InstituteMedicaid Services guidelinesService guidelinesStroke programClinical registryDiagnosis codesClaims dataSampled patientsExpert clinical evaluation
Clinical Care
Overview
Lee H. Schwamm, MD, is an internationally recognized expert in the prevention, diagnosis, and treatment of stroke and transient ischemic attack (TIA). His research and clinical interests focus on stroke in the young and those whose strokes are without apparent cause (called cryptogenic strokes). He has been a leader in stroke clinical research, and has participated in the design or conduct of major trials that have defined how stroke is currently measured and treated, and how the guideline-recommended treatments are actually administered when patients are hospitalized for stroke. He deeply enjoys mentoring emerging leaders in academic medicine, and his work has been recognized by major grants and awards, including several of the highest volunteer awards from the American Heart Association.
In addition to his expertise in stroke, Dr. Schwamm is a leader in digital health and digital transformation. He realized early on that his work as a neurologist could be augmented with the infusion of big data, technology, and focusing on improving the processes of how health care is delivered. This translates to redesigning care delivery through the human-centered lens of the experiences of patients and providers, and letting the clinical problem drive what technology can be used to make things better (and not the other way around). “We have a real opportunity now to start capturing a lot more information about our patients in the parts of their life beyond the clinic and the hospital, such as with monitors, sensors, and smartphones, to regularly collect weight, activity, or blood pressure and transmit those results to the electronic medical record,” Dr. Schwamm says. By doing so, doctors can build a smarter profile of their patients, tailor treatments to them as individuals, and get their risk factors under control faster and more safely.
“I’ve always been drawn to the brain,” says Dr. Schwamm. “This fascination began when I chose to major in philosophy in college, and it drove me to choose neurology as my specialty. Within neurology, I gravitated to stroke because of the new treatments that had just emerged that could halt or reverse the damage being caused to the brain. I was able to make a major contribution by developing the ability to leverage technology to increase access to stroke specialists and improve outcomes for all stroke patients, not just those lucky enough to live near a major stroke center.”
Dr. Schwamm also serves as senior vice president and chief digital health officer for Yale New Haven Health (YNHH) and as a professor in Biomedical Informatics & Data Sciences at Yale School of Medicine (YSM). As the associate dean for digital strategy and transformation, he is leading the development of a new digital health strategy for YSM and YNHH. Dr. Schwamm has done extensive research and is especially interested in patterns of care delivery for stroke in the United States; how patients move from one health system to another during emergencies, before or after their stroke; and opportunities to identify and eliminate inequities in care.
“I often say, my car gets better health care than I do. Most patients show up in my office when they have the equivalent of a flat tire, or have run out of gas, or have an engine that is overheated, metaphorically speaking,” he says, “Our job as health care providers is to intervene before those critical events happen.”
All my goals really boil down to removing the barriers between patients and the care they need, Dr. Schwamm adds. “One way is to build high-reliability systems wherever we can so that we don't rely on people doing the right thing every time with good intention, but rather, we have systems that support us in doing that right thing every time.”
Clinical Specialties
News
News
- November 25, 2024Source: WTNH
How A.I. is Already Predicting Medical Outcomes in Connecticut
- October 24, 2024
Is It AI? Peer Reviewers Struggle to Distinguish LLMs From Human Writing
- October 23, 2024
Telehealth Is Just as Effective as In-person Care, Study Finds
- September 26, 2024Source: CT Mirror
CT companies put AI to work, but regulation remains uncertain
Get In Touch
Contacts
Yale School of Medicine
333 Cedar Street - SHM - I-213 , (PO Box 208067)
New Haven, CT 06520-8067
United States