2024
Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis
Vydyam P, Chand M, Pou S, Winter R, Liebman K, Nilsen A, Doggett J, Riscoe M, Mamoun C. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infectious Diseases 2024, 10: 1405-1413. PMID: 38563132, PMCID: PMC11127568, DOI: 10.1021/acsinfecdis.4c00143.Peer-Reviewed Original ResearchConceptsRadical cureEndochin-like quinolonesAgent of human malariaLethal infection modelTreatment of human babesiosisLow toxicity profileExperimental mouse modelImmunocompetent miceImmunocompromised miceFavorable pharmacological propertiesHuman malariaToxicity profileChronic modelHuman babesiosisAnimal modelsInfection modelPharmacological limitationsActivity in vitroPharmacological propertiesReduce infectionQuinolonesMiceMitochondrial electron transport chainFavorable physicochemical propertiesMonotherapy
2018
Prevention of hemodialysis catheter infections: Ointments, dressings, locks, and catheter hub devices
Golestaneh L, Mokrzycki M. Prevention of hemodialysis catheter infections: Ointments, dressings, locks, and catheter hub devices. Hemodialysis International 2018, 22: s75-s82. PMID: 30411464, DOI: 10.1111/hdi.12703.Peer-Reviewed Original ResearchConceptsBlood stream infectionsAssociated with excess morbidityTunneled central venous cathetersTopical antimicrobial ointmentsCatheter lock solutionCentral venous catheterClinical practice guidelinesVenous cathetersProphylactic useProvision of hemodialysisHemodialysis cathetersAntimicrobial ointmentsOintment applicationHemodialysis populationExcess morbidityCatheterLock solutionsInfectionReduce infectionPractice guidelinesHemodialysisOintmentExit siteMortalityPrevention
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