Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
Edman N, Phal A, Redler R, Schlichthaerle T, Srivatsan S, Ehnes D, Etemadi A, An S, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks D, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry C, Schweppe D, Freedman B, Stewart L, Ekiert D, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. Cell 2024, 187: 3726-3740.e43. PMID: 38861993, PMCID: PMC11246234, DOI: 10.1016/j.cell.2024.05.025.Peer-Reviewed Original ResearchConceptsIntracellular tyrosine kinase domainMitogen-activated protein kinase (MAPK) pathway activationDownstream signaling cascadesCyclic homo-oligomersTyrosine kinase domainReceptor valencyCell fateOligomeric assembliesKinase domainSignaling outcomesSignaling ligandsHomo-oligomersSplice variantsSignaling cascadesCytokine signalingExtracellular domainPathway signalingDevelopmental transitionsProtein building blocksVascular differentiationPathway activationVascular developmentComplexity of signalsModular assemblyTherapeutic applications
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