2020
NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis
Zhang J, Liu J, McGillivray P, Yi C, Lochovsky L, Lee D, Gerstein M. NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis. BMC Bioinformatics 2020, 21: 474. PMID: 33092526, PMCID: PMC7580035, DOI: 10.1186/s12859-020-03758-1.Peer-Reviewed Original ResearchConceptsDNase I hypersensitive sitesMutation rate heterogeneityDNA elementsCancer whole genome sequencesMutational hotspotsMutation burden analysisFunctional genomics dataNon-coding regionsGene regulatory networksWhole Genomes (PCAWG) projectWhole genome sequencesBackground mutation rateBurden analysisChromatin organizationReplication timingGenome sequenceRegulatory networksTranscription factorsHypersensitive sitesGenomic featuresRate heterogeneityGenome ProjectGenomic dataIntegrative methodGamma-Poisson mixture model
2018
Optimal Rates for Phylogenetic Inference and Experimental Design in the Era of Genome-Scale Data Sets
Dornburg A, Su Z, Townsend JP. Optimal Rates for Phylogenetic Inference and Experimental Design in the Era of Genome-Scale Data Sets. Systematic Biology 2018, 68: 145-156. PMID: 29939341, DOI: 10.1093/sysbio/syy047.Peer-Reviewed Original ResearchConceptsPhylogenetic experimental designOptimal rateExperimental design decisionsGenome-scale data setsTheoretical conditionsSite rate heterogeneityData setsComprehensive theoryAccurate predictionTheoryInferenceExperimental designPhylogenetic problemsOptimalityExistence of charactersPredictionRate heterogeneitySetPhylogenetic inferenceData scrutiny
2014
Phylogenetic informativeness reconciles ray-finned fish molecular divergence times
Dornburg A, Townsend JP, Friedman M, Near TJ. Phylogenetic informativeness reconciles ray-finned fish molecular divergence times. BMC Ecology And Evolution 2014, 14: 169. PMID: 25103329, PMCID: PMC4236503, DOI: 10.1186/s12862-014-0169-0.Peer-Reviewed Original ResearchConceptsMolecular age estimatesMolecular divergence timesDivergence timesSequence dataMolecular divergence time estimationMitochondrial sequence dataPhylogenetic informativeness profilesDivergence time estimationRay-finned fishesTree of lifeMolecular clock methodsSubstitution rate heterogeneityMolecular clock modelBranch length estimatesPhylogenetic informativenessNuclear sequencesRecent divergenceMolecular clockIndividual genesPhylogenetic inferenceDNA sequence alignmentRate heterogeneityFossil recordSequence alignmentClock method
2006
Mitochondrial DNA reveals a strong phylogeographic structure in the badger across Eurasia
MARMI J, LÓPEZ‐GIRÁLDEZ F, MACDONALD DW, CALAFELL F, ZHOLNEROVSKAYA E, DOMINGO‐ROURA X. Mitochondrial DNA reveals a strong phylogeographic structure in the badger across Eurasia. Molecular Ecology 2006, 15: 1007-1020. PMID: 16599963, DOI: 10.1111/j.1365-294x.2006.02747.x.Peer-Reviewed Original ResearchConceptsPhylogeographic groupsAsian badgersMitochondrial DNAMitochondrial DNA control regionStrong phylogeographic structureDNA control regionWidespread geographic rangeMedian-joining networkTamura-Nei modelEurasian badgerPhylogeographic structureGenetic structuringBiogeographic processesMolecular varianceGroups of populationsLarge geographic variabilityEvolutionary significanceMantel testEnd of PlioceneMolecular dataControl regionGenetic variationGeographic rangeMorphological charactersRate heterogeneity
1997
Mitochondrial DNA Rates and Biogeography in European Newts (Genus Euproctus)
Caccone A, Milinkovitch M, Sbordoni V, Powell J. Mitochondrial DNA Rates and Biogeography in European Newts (Genus Euproctus). Systematic Biology 1997, 46: 126-144. PMID: 11975350, DOI: 10.1093/sysbio/46.1.126.Peer-Reviewed Original ResearchConceptsCytochrome b geneB geneDivergence timesMitochondrial DNA genesTime of divergenceMolecular clock hypothesisSardinia-Corsica microplateRate of evolutionMtDNA rateGene flowCladogenic eventsVicariant eventsMolecular divergenceTajima's testSequence divergenceRibosomal genesDNA genesPhylogenetic perspectiveVicariant distributionPhylogenetic studiesEuropean newtsRibosomal RNAClock hypothesisSequence dataRate heterogeneity
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