2019
Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A)
Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y. Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A). European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 1952-1965. PMID: 31175396, PMCID: PMC6810698, DOI: 10.1007/s00259-019-04357-w.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2AHigh specific binding signalsNonhuman primatesPET imagingHigh brain uptakeRegional distribution volumesBrain uptakeSynaptic densityOne-tissue compartment modelExcellent imaging agentRegional time-activity curvesVivo biomarkersArterial samplesSpecific binding signalsPsychiatric diseasesTime-activity curvesAlzheimer's diseaseDistribution volumeNeuropsychiatric disordersRadioactive metabolitesRhesus monkeysPET radiotracersVivo evaluationDiseaseImaging agent
1983
GABA from putrescine is bound in macromolecular form in keratinocytes
Canellakis Z, Milstone L, Marsh L, Young P, Bondy P. GABA from putrescine is bound in macromolecular form in keratinocytes. Life Sciences 1983, 33: 599-603. PMID: 6192309, DOI: 10.1016/0024-3205(83)90247-3.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidAcid-precipitable materialNeurotransmitter gamma-aminobutyric acidTotal cell-associated radioactivityTCA-precipitable radioactivityTCA-soluble radioactivityCultured human keratinocytesTCA-soluble fractionCell-associated radioactivityHuman foreskin keratinocytesTCA-precipitable materialAcid-soluble radioactivityRadioactive metabolitesSoluble radioactivityForeskin keratinocytesStratified culturesHuman keratinocytesKeratinocytesTrichloroacetic acidMacromolecular formRadioactivity
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