VGF function in depression and antidepressant efficacy
Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Molecular Psychiatry 2017, 23: 1632-1642. PMID: 29158577, PMCID: PMC5962361, DOI: 10.1038/mp.2017.233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressionDepressive DisorderDown-RegulationFemaleHippocampusHumansKetamineMaleMiceMice, Inbred C57BLMiddle AgedNerve Growth FactorsNeuronsNeuropeptidesNucleus AccumbensReceptors, AMPASex FactorsSignal TransductionStress, PsychologicalTOR Serine-Threonine KinasesUp-RegulationConceptsChronic social defeat stressDepression-like behaviorBrain-derived neurotrophic factorSocial defeat stressNucleus accumbensAntidepressant efficacyAntidepressant responseDefeat stressFloxed micePro-depressant effectsRapid antidepressant efficacyBDNF/TrkBIsoxazolepropionic acid (AMPA) receptorsWild-type miceDepressed human subjectsBDNF translationTLQP-62VGF levelsAAV-CreAntidepressant behaviorNeurotrophic factorSwim testDorsal hippocampusInhibitory interneuronsVGF expressionAdministration of ketamine for unipolar and bipolar depression
Kraus C, Rabl U, Vanicek T, Carlberg L, Popovic A, Spies M, Bartova L, Gryglewski G, Papageorgiou K, Lanzenberger R, Willeit M, Winkler D, Rybakowski JK, Kasper S. Administration of ketamine for unipolar and bipolar depression. International Journal Of Psychiatry In Clinical Practice 2017, 21: 2-12. PMID: 28097909, DOI: 10.1080/13651501.2016.1254802.Peer-Reviewed Original ResearchConceptsBipolar depressionSide effectsResponse rateMost common side effectsLong-term side effectsHamilton Depression Rating ScaleAntidepressant response ratesNausea/vomitingOpen-label trialRapid antidepressant efficacyTreatment-resistant depressionAnti-suicidal effectsCommon side effectsEfficacious treatment optionPrimary outcome measureAdministration of ketamineDepression Rating ScaleNew administration routesWeb of ScienceKetamine efficacyResistant depressionAntidepressant efficacyRelapse rateAntidepressant responseSafety profile
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