2019
Modulation of the pupillary response by the content of visual working memory
Zokaei N, Board A, Manohar S, Nobre A. Modulation of the pupillary response by the content of visual working memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22802-22810. PMID: 31636213, PMCID: PMC6842592, DOI: 10.1073/pnas.1909959116.Peer-Reviewed Original ResearchConceptsWorking memoryContents of visual working memoryInternal shifts of attentionVisual stimuliStimulus brightnessPupillary responseWorking-memory taskVisual working memoryTop-down modulationShifts of attentionPupil responseTop-down controlRetention delayTask-relevantCognitive factorsTemporal expectationsSensory recruitmentStimuliMemoryStimulus orientationPupilsPupil diameterBrightnessActivation of sensory receptorsVisual stimulation
2008
Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer
Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J. Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer. Molecular Therapy 2008, 16: 458-465. PMID: 18209734, PMCID: PMC2842085, DOI: 10.1038/sj.mt.6300389.Peer-Reviewed Original ResearchConceptsLeber congenital amaurosisAnimal modelsCongenital amaurosisReversal of blindnessRetinal pigment epithelium cellsWeeks of injectionPigment epithelium cellsRPE65 formDose of vectorAppropriate target cellsVisual acuityVisual deficitsHistopathologic analysisAdeno-associated virusERG responsesRPE65 mutationsSubretinal deliveryEpithelium cellsMutant miceMinimal toxicityProtein expressionTarget cellsPupillary responseElectroretinogramAmaurosis
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