Intranasal delivery of antibodies bypasses the blood‐brain barrier and results in significantly higher central nervous system levels than systemic administration
Boroumand S, Kumar N, Lochhead J, Pizzo M, Nehra G, Thorne R. Intranasal delivery of antibodies bypasses the blood‐brain barrier and results in significantly higher central nervous system levels than systemic administration. The FASEB Journal 2018, 32: lb617-lb617. DOI: 10.1096/fasebj.2018.32.1_supplement.lb617.Peer-Reviewed Original ResearchBlood-brain barrierCentral nervous systemBlood-cerebrospinal-fluid barrierIntranasal deliveryDelivery of antibodiesCerebral blood vesselsIntranasal routePotential of intranasal deliverySystemic administrationPerivascular spacesCNS target sitesCentral nervous system levelBlood vesselsNervous system levelNon-invasive strategyOlfactory bulbIntact in vivoSystemic deliveryTransports IgGPassive immunotherapyTreatment of neurological diseasesIgG transportCranial nervesQuantitative distribution studiesTherapeutic strategies
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