General Solid-Phase Synthesis Approach To Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries. Identification of Potent Cathepsin D Inhibitors
Lee C, Kick E, Ellman J. General Solid-Phase Synthesis Approach To Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries. Identification of Potent Cathepsin D Inhibitors. Journal Of The American Chemical Society 1998, 120: 9735-9747. DOI: 10.1021/ja981812m.Peer-Reviewed Original ResearchSolid-phase synthesis approachSynthesis approachSolid-phase synthesisExpedient solid-phase synthesisProtease inhibitor libraryAvailable precursorsSynthesis sequenceSeparate compoundsStereoselective reductionPotent small molecule inhibitorsSmall molecule inhibitorsOverall yieldDiverse functionalitiesEnzyme classesProtease targetsMolecule inhibitorsGeneral design principlesAspartyl protease inhibitorsCathepsin D inhibitorInhibitor libraryPure inhibitorGeneral methodBondsAmino acidsCompounds
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