IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION
Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Christian DA, Pritchard G, Fang Q, Buza EL, Jain D, Elloso MM, López CB, Hunter CA. IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION. PLOS Pathogens 2017, 13: e1006173. PMID: 28129374, PMCID: PMC5305264, DOI: 10.1371/journal.ppat.1006173.Peer-Reviewed Original ResearchConceptsParainfluenza virus infectionTh2 responsesIL-27Control miceT cellsVirus infectionParamyxovirus infectionDisease severityWeight lossPathogenic Th2 responsesQuality of CD4Type 2 immunopathologyT-cell depletionT cell responsesSevere lung lesionsPopulation of IFNParainfluenza infectionsPulmonary eosinophilsRespiratory paramyxovirusesT helperCell depletionLung lesionsImmune responseLimit pathologyCD4
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