Crystal Structure and Substrate Specificity of PTPN12
Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W, Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun J, Yu X. Crystal Structure and Substrate Specificity of PTPN12. Cell Reports 2016, 15: 1345-1358. PMID: 27134172, DOI: 10.1016/j.celrep.2016.04.016.Peer-Reviewed Original ResearchConceptsSubstrate specificityPhosphorylation sitesStructurally plastic regionCdk2 phosphorylation sitesDesign specific inhibitorsSurface loopsCharged residuesMolecular basisTumor suppressorPTPN12Physiological processesBinding pocketSpecific inhibitorsCrystallographic studiesResiduesStructural featuresDesphosphorylationSubstrateCDK2SuppressorCrystal structureSites
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