Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Wu J, Zhang J, Chen X, Wettschurack K, Que Z, Deming B, Olivero-Acosta M, Cui N, Eaton M, Zhao Y, Li S, Suzuki M, Chen I, Xiao T, Halurkar M, Mandal P, Yuan C, Xu R, Koss W, Du D, Chen F, Wu L, Yang Y. Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids. Molecular Psychiatry 2024, 29: 2424-2437. PMID: 38499656, DOI: 10.1038/s41380-024-02518-4.Peer-Reviewed Original ResearchAutism spectrum disorderSpine densityAssociated with autism spectrum disorderLower spine densitySynaptic transmissionHuman cellsPost-synapseProtein-truncating mutationsNeurodevelopmental disorder affecting 1Phagocytosis of synapsesNeuro-immune responsesImpaired learningIntellectual disabilityNeuro-immune interactionsHuman genetic studiesRestoring synaptic transmissionReduced synaptic transmissionAblation of microgliaSpectrum disorderResident immune cellsHuman cerebral organoid modelCerebral organoidsBrain developmentCerebral organoid modelSCN2A mutations
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