Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes
Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes. Schizophrenia Bulletin 2014, 40: 1285-1299. PMID: 24664977, PMCID: PMC4193716, DOI: 10.1093/schbul/sbu045.Peer-Reviewed Original ResearchConceptsCopy number variationsProtein-protein interactionsSchizophrenia susceptibility genesCandidate genesNumber variationsDisease-common variant hypothesisGlobal overview of genesProportion of missing heritabilityProtein-protein interaction dataSusceptibility genesAnalysis of copy number variationsIntegrated analysis of copy number variationsProtein products of genesIntegration of genesSchizophrenia-associated proteinsProducts of genesOverview of genesSchizophrenia candidate genesSchizophrenia risk genesVariant hypothesisTop genesGenetic heterogeneityFunctional characterizationRisk genesGenetic variantsmiRIAD—integrating microRNA inter- and intragenic data
Hinske L, França G, Torres H, Ohara D, Lopes-Ramos C, Heyn J, Reis L, Ohno-Machado L, Kreth S, Galante P. miRIAD—integrating microRNA inter- and intragenic data. Database 2014, 2014: bau099. PMID: 25288656, PMCID: PMC4186326, DOI: 10.1093/database/bau099.Peer-Reviewed Original ResearchConceptsProtein-coding genesIntragenic miRNAsHost genesGene expressionProtein-protein interaction dataSmall non-coding RNAsHost gene functionHost gene expressionMiRNA binding sitesNon-coding RNAsMajority of miRNAsGene functionGenomic contextFunctional annotationFunctional network analysisTarget mRNAsExpression correlationExonic regionsGenesMiRNAsDifferent tissuesInteraction dataBinding sitesGenomic classificationSilico validation
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