2018
An evolutionarily conserved gene family encodes proton-selective ion channels
Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 2018, 359: 1047-1050. PMID: 29371428, PMCID: PMC5845439, DOI: 10.1126/science.aao3264.Peer-Reviewed Original ResearchConceptsProton-selective ion channelIon channelsProton channelComparative transcriptome analysisTaste receptor cellsWidespread tissue distributionEvolutionary conservationEukaryotic cellsGene familyMurine geneTranscriptome analysisReceptor cellsElectrical signalingProton conductanceBroader roleMouse taste receptor cellsTissue distributionCellsOrthologsGenesSignalingProteinConservationPhysiologyFamily
2010
Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe T, Pang IK, Iwasaki A. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature Immunology 2010, 11: 404-410. PMID: 20383149, PMCID: PMC2857582, DOI: 10.1038/ni.1861.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCells, CulturedCytokinesDendritic CellsGenetic EngineeringGolgi ApparatusHydrogen-Ion ConcentrationIon ChannelsMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMonensinNLR Family, Pyrin Domain-Containing 3 ProteinOncogene Proteins, ViralOrthomyxoviridaeOrthomyxoviridae InfectionsPotassium ChlorideProtein TransportProtonsSequence DeletionToll-Like Receptor 7Viral Matrix ProteinsVirus Replication
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