Base‐Controlled Completely Selective Linear or Branched Rhodium(I)‐Catalyzed C−H ortho‐Alkylation of Azines without Preactivation
Tran G, Hesp K, Mascitti V, Ellman J. Base‐Controlled Completely Selective Linear or Branched Rhodium(I)‐Catalyzed C−H ortho‐Alkylation of Azines without Preactivation. Angewandte Chemie 2017, 129: 5993-5997. DOI: 10.1002/ange.201702409.Peer-Reviewed Original ResearchCatalytic systemBranched selectivityExcellent functional group compatibilityComplete branched selectivityFunctional group compatibilityQuaternary carbon centerBranched alkylationOrtho alkylationEthyl methacrylateOperational simplicityCarbon centerGroup compatibilitySelective linearAzinesCatalytic baseRapid accessSelectivityAlkylationComplete linearBroad scopeAcrylateMethacrylateAcrylamidePharmaceuticalsLinearBase‐Controlled Completely Selective Linear or Branched Rhodium(I)‐Catalyzed C−H ortho‐Alkylation of Azines without Preactivation
Tran G, Hesp KD, Mascitti V, Ellman JA. Base‐Controlled Completely Selective Linear or Branched Rhodium(I)‐Catalyzed C−H ortho‐Alkylation of Azines without Preactivation. Angewandte Chemie International Edition 2017, 56: 5899-5903. PMID: 28429455, PMCID: PMC5558092, DOI: 10.1002/anie.201702409.Peer-Reviewed Original ResearchConceptsCatalytic systemBranched selectivityExcellent functional group compatibilityComplete branched selectivityFunctional group compatibilityQuaternary carbon centerBranched alkylationOrtho alkylationEthyl methacrylateOperational simplicityH alkylationCarbon centerGroup compatibilitySelective linearAzinesCatalytic baseRapid accessSelectivityAlkylationComplete linearBroad scopeAcrylateMethacrylateAcrylamidePharmaceuticals
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