2009
COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP*
Cayli S, Klug J, Chapiro J, Fröhlich S, Krasteva G, Orel L, Meinhardt A. COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP*. Journal Of Biological Chemistry 2009, 284: 34944-34953. PMID: 19826004, PMCID: PMC2787357, DOI: 10.1074/jbc.m109.037952.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAdenosine TriphosphateAmino Acid SequenceAnimalsCell Cycle ProteinsCOP9 Signalosome ComplexHumansMiceMolecular Sequence DataMultiprotein ComplexesNIH 3T3 CellsPeptide HydrolasesProtein BindingProtein SubunitsRecombinant Fusion ProteinsUbiquitinationValosin Containing ProteinConceptsP97/valosin-containing proteinValosin-containing proteinUbiquitin/proteasome systemCOP9 signalosomeUbiquitination statusUbiquitinated proteinsProteasome degrades ubiquitinated proteinsATP-dependent mannerProteasome regulatory particleATP-dependent complexesUbiquitin E3 ligasesOligoubiquitin chainsCSN complexE3 ligasesPolyubiquitinated substratesRegulatory particleIsopeptidase activityProteasome systemDeubiquitinase USP15Subunit 5ProteinSignalosomeDegradation pathwayCSN5Key mediator
1999
Structure and functional analyses of the 26S proteasome subunits from plants – Plant 26S proteasome
Fu H, Girod P, Doelling J, van Nocker S, Hochstrasser M, Finley D, Vierstra R. Structure and functional analyses of the 26S proteasome subunits from plants – Plant 26S proteasome. Molecular Biology Reports 1999, 26: 137-146. PMID: 10363660, DOI: 10.1023/a:1006926322501.Peer-Reviewed Original ResearchConceptsProteasome degrades ubiquitinated proteinsUbiquitin fusion degradation (UFD) pathwayStructure/function analysisAAA-ATPase subunitsC-terminal motifDegradation of proteinsRegulatory particle subunitsCore particlesPlant 26SRpn10 geneArabidopsis genesYeast counterpartMoss PhyscomitrellaArabidopsis thalianaPlant hormonesUbiquitin systemProteasome genesDevelopmental programHomologous recombinationProteolytic complexPlant subunitsReverse geneticsUbiquitinated proteinsUbiquitin conjugatesVivo function
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