Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques
Zhou Z, Korteland S, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M, Schenkel T, Diagbouga M, Wentzel J, Fragiadaki M, Evans P. Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques. Atherosclerosis 2024, 398: 118622. PMID: 39413592, DOI: 10.1016/j.atherosclerosis.2024.118622.Peer-Reviewed Original ResearchConceptsShear stressPhysiological shear stressComputational fluid dynamicsDiseased arteriesHealthy arteriesGene Ontology termsFluid dynamicsSingle-cell RNA sequencingApoptotic gene expressionEffect of physiological shear stressPromote vascular homeostasisOntology termsRNA sequencingFunctional enrichmentEndothelial cellsGene expressionRisk of cardiovascular complications
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