Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer
Babar M, Nassar A, Nie X, Zhang T, He J, Yeung J, Norris P, Ogura H, Muldoon A, Chen L, Libreros S. Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer. Metabolites 2024, 14: 314. PMID: 38921449, PMCID: PMC11205484, DOI: 10.3390/metabo14060314.Peer-Reviewed Original ResearchResolution of inflammationPro-resolving mediatorsTherapeutic effectOral squamous cell carcinomaT cell responsesSquamous cell carcinomaEicosapentaenoic acid derivativeExcessive neutrophil infiltrationDendritic cell migrationEndogenous lipid mediatorsMetastasis of cancer cellsPro-inflammatory cytokinesSpecialized pro-resolving mediatorsCell carcinomaTumor microenvironmentIschemia-related injuryLung inflammationTumor progressionNeutrophil infiltrationCell debris clearanceCystic fibrosisLung cancerAcute inflammationHerpes virusTherapeutic approachesLipid mediators in neutrophil biology: inflammation, resolution and beyond
Ghodsi A, Hidalgo A, Libreros S. Lipid mediators in neutrophil biology: inflammation, resolution and beyond. Current Opinion In Hematology 2024, 31: 175-192. PMID: 38727155, PMCID: PMC11301784, DOI: 10.1097/moh.0000000000000822.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsAcute inflammationLipid mediatorsResolution of acute inflammationChronic inflammatory disordersExcessive neutrophil infiltrationCell surface G protein-coupled receptorsEndogenous lipid mediatorsTissue repair mechanismsResolution of inflammationPro-resolving mediatorsNeutrophil infiltrationChronic inflammationIschemic eventsInflammatory disordersInflammatory insultInflammation sitesInflammationNeutrophil phagocytosisCardiovascular diseaseNeutrophil functionNeutrophilsTherapeutic agentsNeutrophil heterogeneityNeutrophil apoptosis
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