2017
Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery
Lei DL, Song E, Gaudin A, Saltzman WM. Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery. Computerized Medical Imaging And Graphics 2017, 62: 34-40. PMID: 28927549, PMCID: PMC5716935, DOI: 10.1016/j.compmedimag.2017.08.001.Peer-Reviewed Original ResearchConceptsDistribution of nanoparticlesConvection-enhanced deliveryNanoparticlesFluorescent imagingFluorescent image analysisAccurate threshold valuesPromising methodFluorescent reporter systemDeliveryNanotechnologyEffectiveness of deliverySubKey parametersReporter systemFixed-threshold methodCurrent methods
2012
Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method
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