Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression*
Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression*. Journal Of Biological Chemistry 2010, 285: 9180-9189. PMID: 20071344, PMCID: PMC2838337, DOI: 10.1074/jbc.m109.077958.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 4Cell DifferentiationEmbryonic Stem CellsGene Expression RegulationHomeodomain ProteinsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsLeukemia Inhibitory FactorMiceModels, BiologicalNanog Homeobox ProteinSignal TransductionSTAT3 Transcription FactorConceptsES cell self-renewalES cell differentiationCell Self-RenewalSomatic cell reprogrammingCell differentiationKruppel-like factor 4Embryonic stemLeukemia inhibitory factorBone morphogenetic protein 4Cell reprogrammingPromoter region of NanogSelf-RenewalTranscription factor Kruppel-like factor 4KLF4 gene expressionMaintenance of pluripotencyFamily proteinsFactor 4Differentiation of ES cellsPromoter regionGene expressionES cellsExpression of NanogOverexpressing KLF4Protein 4Nanog expression
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