Abstract 93: An endogenous molecular brake preventing APOBEC-driven tumor mutational burden, heterogeneity and therapy resistance
Mu P, Li X, Wang Y, Wang T, Deng S. Abstract 93: An endogenous molecular brake preventing APOBEC-driven tumor mutational burden, heterogeneity and therapy resistance. Cancer Research 2023, 83: 93-93. DOI: 10.1158/1538-7445.am2023-93.Peer-Reviewed Original ResearchTumor mutational burdenTherapy resistanceMutational burdenMolecular brakeSingle cell RNA-seqDriver mutationsDrivers of mutagenesisAmerican Association for Cancer Research annual meetingsClinical outcomes of patientsCRISPR library screensRNA-seqExome-sequencingScRNA-seqOutcomes of patientsLibrary screeningFunctional screeningNon-malignant cellsCell-intrinsic mechanismsPromote heterogeneityMutagenesisMutated genesAPOBEC proteinsMutational signaturesMutationsPotential therapeutic target
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